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Items: 1 to 20 of 228

1.

Binding of CYP2C9 with diverse drugs and its implications for metabolic mechanism.

Wang JF, Yan JY, Wei DQ, Chou KC.

Med Chem. 2009 May;5(3):263-70.

PMID:
19442216
2.

Crystal structure of human cytochrome P450 2C9 with bound warfarin.

Williams PA, Cosme J, Ward A, Angove HC, Matak Vinković D, Jhoti H.

Nature. 2003 Jul 24;424(6947):464-8. Epub 2003 Jul 13.

PMID:
12861225
3.

Designing better drugs: predicting cytochrome P450 metabolism.

de Groot MJ.

Drug Discov Today. 2006 Jul;11(13-14):601-6.

PMID:
16793528
4.

New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I.

Mo SL, Zhou ZW, Yang LP, Wei MQ, Zhou SF.

Curr Drug Metab. 2009 Dec;10(10):1075-126. Review.

PMID:
20167001
5.

Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone.

Williams PA, Cosme J, Vinkovic DM, Ward A, Angove HC, Day PJ, Vonrhein C, Tickle IJ, Jhoti H.

Science. 2004 Jul 30;305(5684):683-6. Epub 2004 Jul 15.

6.

Polymorphism of human cytochrome P450 enzymes and its clinical impact.

Zhou SF, Liu JP, Chowbay B.

Drug Metab Rev. 2009;41(2):89-295. doi: 10.1080/03602530902843483. Review.

PMID:
19514967
7.

Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures and in silico modeling.

Dong D, Wu B.

Drug Metab Rev. 2012 Feb;44(1):1-17. doi: 10.3109/03602532.2011.645581. Review.

PMID:
22242930
8.

Prediction of binding modes for ligands in the cytochromes P450 and other heme-containing proteins.

Kirton SB, Murray CW, Verdonk ML, Taylor RD.

Proteins. 2005 Mar 1;58(4):836-44.

PMID:
15651036
9.

New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part II.

Mo SL, Zhou ZW, Yang LP, Wei MQ, Zhou SF.

Curr Drug Metab. 2009 Dec;10(10):1127-50. Review.

PMID:
20167000
10.

Human cytochromes P450 in the metabolism of drugs: new molecular models of enzyme-substrate interactions.

Lewis DF, Ito Y.

Expert Opin Drug Metab Toxicol. 2008 Sep;4(9):1181-6. doi: 10.1517/17425255.4.9.1181 . Review.

PMID:
18721112
11.

Human P450s involved in drug metabolism and the use of structural modelling for understanding substrate selectivity and binding affinity.

Lewis DF, Ito Y.

Xenobiotica. 2009 Aug;39(8):625-35. doi: 10.1080/00498250903000255. Review.

PMID:
19514836
12.

Pharmacophore modeling of cytochromes P450.

de Groot MJ, Ekins S.

Adv Drug Deliv Rev. 2002 Mar 31;54(3):367-83. Review.

PMID:
11922953
13.

Molecular modeling used to evaluate CYP2C9-dependent metabolism: homology modeling, molecular dynamics and docking simulations.

Mendieta-Wejebe JE, Correa-Basurto J, García-Segovia EM, Ceballos-Cancino G, Rosales-Hernández MC.

Curr Drug Metab. 2011 Jul;12(6):533-48. Review.

PMID:
21486213
14.

A refined 3-dimensional QSAR of cytochrome P450 2C9: computational predictions of drug interactions.

Rao S, Aoyama R, Schrag M, Trager WF, Rettie A, Jones JP.

J Med Chem. 2000 Jul 27;43(15):2789-96.

PMID:
10956186
15.

Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures and in silico modeling.

Dong D, Wu B, Chow D, Hu M.

Drug Metab Rev. 2012 May;44(2):192-208. doi: 10.3109/03602532.2011.645580. Epub 2012 Jan 18. Review.

PMID:
22251142
16.
17.
18.

Cytochrome P450.

Poulos TL.

Curr Opin Struct Biol. 1995 Dec;5(6):767-74. Review.

PMID:
8749364
19.

High-throughput enzymology and combinatorial mutagenesis for mining cytochrome P450 functions.

Urban P, Truan G, Pompon D.

Expert Opin Drug Metab Toxicol. 2008 Jun;4(6):733-47. doi: 10.1517/17425255.4.6.733 . Review.

PMID:
18611114
20.

Exploration of enzyme-ligand interactions in CYP2D6 & 3A4 homology models and crystal structures using a novel computational approach.

Kjellander B, Masimirembwa CM, Zamora I.

J Chem Inf Model. 2007 May-Jun;47(3):1234-47. Epub 2007 Mar 24.

PMID:
17381082

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