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Items: 1 to 20 of 133


Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.

Zhou Z, Zhen J, Karpowich NK, Law CJ, Reith ME, Wang DN.

Nat Struct Mol Biol. 2009 Jun;16(6):652-7. doi: 10.1038/nsmb.1602. Epub 2009 May 10.


Structural basis for action by diverse antidepressants on biogenic amine transporters.

Wang H, Goehring A, Wang KH, Penmatsa A, Ressler R, Gouaux E.

Nature. 2013 Nov 7;503(7474):141-5. doi: 10.1038/nature12648. Epub 2013 Oct 13.


Molecular basis for selective serotonin reuptake inhibition by the antidepressant agent fluoxetine (Prozac).

Andersen J, Stuhr-Hansen N, Zachariassen LG, Koldsø H, Schiøtt B, Strømgaard K, Kristensen AS.

Mol Pharmacol. 2014 May;85(5):703-14. doi: 10.1124/mol.113.091249. Epub 2014 Feb 10.


Relationship between brain serotonin transporter binding, plasma concentration and behavioural effect of selective serotonin reuptake inhibitors.

Hirano K, Kimura R, Sugimoto Y, Yamada J, Uchida S, Kato Y, Hashimoto H, Yamada S.

Br J Pharmacol. 2005 Mar;144(5):695-702.


LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake.

Zhou Z, Zhen J, Karpowich NK, Goetz RM, Law CJ, Reith ME, Wang DN.

Science. 2007 Sep 7;317(5843):1390-3. Epub 2007 Aug 9.


Association of changes in norepinephrine and serotonin transporter expression with the long-term behavioral effects of antidepressant drugs.

Zhao Z, Zhang HT, Bootzin E, Millan MJ, O'Donnell JM.

Neuropsychopharmacology. 2009 May;34(6):1467-81. doi: 10.1038/npp.2008.183. Epub 2008 Oct 15.


Essential Contributions of Serotonin Transporter Inhibition to the Acute and Chronic Actions of Fluoxetine and Citalopram in the SERT Met172 Mouse.

Nackenoff AG, Moussa-Tooks AB, McMeekin AM, Veenstra-VanderWeele J, Blakely RD.

Neuropsychopharmacology. 2016 Jun;41(7):1733-41. doi: 10.1038/npp.2015.335. Epub 2015 Oct 30.


Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters.

Andersen J, Stuhr-Hansen N, Zachariassen L, Toubro S, Hansen SM, Eildal JN, Bond AD, Bøgesø KP, Bang-Andersen B, Kristensen AS, Strømgaard K.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12137-42. doi: 10.1073/pnas.1103060108. Epub 2011 Jul 5.


Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants.

Henry LK, Field JR, Adkins EM, Parnas ML, Vaughan RA, Zou MF, Newman AH, Blakely RD.

J Biol Chem. 2006 Jan 27;281(4):2012-23. Epub 2005 Nov 3.


Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants.

Andersen J, Taboureau O, Hansen KB, Olsen L, Egebjerg J, Strømgaard K, Kristensen AS.

J Biol Chem. 2009 Apr 10;284(15):10276-84. doi: 10.1074/jbc.M806907200. Epub 2009 Feb 12.


Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level.

Benmansour S, Cecchi M, Morilak DA, Gerhardt GA, Javors MA, Gould GG, Frazer A.

J Neurosci. 1999 Dec 1;19(23):10494-501.


Synthesis, molecular docking and binding studies of selective serotonin transporter inhibitors.

Nencetti S, Mazzoni MR, Ortore G, Lapucci A, Giuntini J, Orlandini E, Banti I, Nuti E, Lucacchini A, Giannaccini G, Rossello A.

Eur J Med Chem. 2011 Mar;46(3):825-34. doi: 10.1016/j.ejmech.2010.12.018. Epub 2010 Dec 22.


Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter.

Andersen J, Olsen L, Hansen KB, Taboureau O, Jørgensen FS, Jørgensen AM, Bang-Andersen B, Egebjerg J, Strømgaard K, Kristensen AS.

J Biol Chem. 2010 Jan 15;285(3):2051-63. doi: 10.1074/jbc.M109.072587. Epub 2009 Nov 5.


Monoamine transporter gene polymorphisms and antidepressant response in koreans with late-life depression.

Kim H, Lim SW, Kim S, Kim JW, Chang YH, Carroll BJ, Kim DK.

JAMA. 2006 Oct 4;296(13):1609-18.


Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex.

Bymaster FP, Zhang W, Carter PA, Shaw J, Chernet E, Phebus L, Wong DT, Perry KW.

Psychopharmacology (Berl). 2002 Apr;160(4):353-61. Epub 2002 Jan 29.


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