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Items: 1 to 20 of 108

1.

Development of an in-capillary approach to nanoscale automated in vitro cytochromes p450 assays.

Nicoli R, Curcio R, Rudaz S, Veuthey JL.

J Med Chem. 2009 Apr 23;52(8):2192-5. doi: 10.1021/jm900201b.

PMID:
19326942
2.
3.

A novel incubation direct injection LC/MS/MS technique for in vitro drug metabolism screening studies involving the CYP 2D6 and the CYP 3A4 isozymes.

Bhoopathy S, Xin B, Unger SE, Karnes HT.

J Pharm Biomed Anal. 2005 Apr 1;37(4):739-49. Epub 2004 Dec 30.

PMID:
15797796
4.

Application of a generic fast gradient liquid chromatography tandem mass spectrometry method for the analysis of cytochrome P450 probe substrates.

Ayrton J, Plumb R, Leavens WJ, Mallett D, Dickins M, Dear GJ.

Rapid Commun Mass Spectrom. 1998;12(5):217-24.

PMID:
9519475
5.

Automated high throughput ADME assays for metabolic stability and cytochrome P450 inhibition profiling of combinatorial libraries.

Jenkins KM, Angeles R, Quintos MT, Xu R, Kassel DB, Rourick RA.

J Pharm Biomed Anal. 2004 Mar 10;34(5):989-1004.

PMID:
15019033
6.

Sub one minute inhibition assays for the major cytochrome P450 enzymes utilizing ultra-performance liquid chromatography/tandem mass spectrometry.

Rainville PD, Wheaton JP, Alden PG, Plumb RS.

Rapid Commun Mass Spectrom. 2008 May;22(9):1345-50. doi: 10.1002/rcm.3465.

PMID:
18381621
7.
8.

In vitro LC-MS cocktail assays to simultaneously determine human cytochrome P450 activities.

Dixit V, Hariparsad N, Desai P, Unadkat JD.

Biopharm Drug Dispos. 2007 Jul;28(5):257-62.

PMID:
17443647
9.

Evaluation of an in-capillary approach for performing quantitative cytochrome P450 activity studies.

Curcio R, Nicoli R, Rudaz S, Veuthey JL.

Anal Bioanal Chem. 2010 Nov;398(5):2163-71. doi: 10.1007/s00216-010-4175-9. Epub 2010 Sep 12.

PMID:
20835864
10.

Development of immobilized enzyme reactors based on human recombinant cytochrome P450 enzymes for phase I drug metabolism studies.

Nicoli R, Bartolini M, Rudaz S, Andrisano V, Veuthey JL.

J Chromatogr A. 2008 Oct 3;1206(1):2-10. doi: 10.1016/j.chroma.2008.05.080. Epub 2008 Jun 14.

PMID:
18556005
11.
12.

Coupling ultra high-pressure liquid chromatography with single quadrupole mass spectrometry for the analysis of a complex drug mixture.

Schappler J, Nicoli R, Nguyen D, Rudaz S, Veuthey JL, Guillarme D.

Talanta. 2009 Apr 30;78(2):377-87. doi: 10.1016/j.talanta.2008.11.029. Epub 2008 Nov 27.

PMID:
19203598
13.

Integrated in vitro analysis for the in vivo prediction of cytochrome P450-mediated drug-drug interactions.

McGinnity DF, Waters NJ, Tucker J, Riley RJ.

Drug Metab Dispos. 2008 Jun;36(6):1126-34. doi: 10.1124/dmd.108.020446. Epub 2008 Mar 20.

14.

Inhibition of cytochrome P450 2D6: structure-activity studies using a series of quinidine and quinine analogues.

Hutzler JM, Walker GS, Wienkers LC.

Chem Res Toxicol. 2003 Apr;16(4):450-9.

PMID:
12703961
15.

Evaluation of recombinant cytochrome P450 enzymes as an in vitro system for metabolic clearance predictions.

Stringer RA, Strain-Damerell C, Nicklin P, Houston JB.

Drug Metab Dispos. 2009 May;37(5):1025-34. doi: 10.1124/dmd.108.024810. Epub 2009 Feb 5.

16.

A simplified method to determine five cytochrome p450 probe drugs by HPLC in a single run.

Liu Y, Jiao J, Zhang C, Lou J.

Biol Pharm Bull. 2009 Apr;32(4):717-20.

17.

The role of human hepatic cytochrome P450 isozymes in the metabolism of racemic 3,4-methylenedioxy-methamphetamine and its enantiomers.

Meyer MR, Peters FT, Maurer HH.

Drug Metab Dispos. 2008 Nov;36(11):2345-54. doi: 10.1124/dmd.108.021543. Epub 2008 Aug 25.

18.

Electrochemistry-mass spectrometry in drug metabolism and protein research.

Permentier HP, Bruins AP, Bischoff R.

Mini Rev Med Chem. 2008 Jan;8(1):46-56. Review.

PMID:
18220984
19.

Strategies to in vitro assessment of major human CYP enzyme activities by using liquid chromatography tandem mass spectrometry.

Lahoz A, Donato MT, Castell JV, Gómez-Lechón MJ.

Curr Drug Metab. 2008 Jan;9(1):12-9. Review.

PMID:
18220567
20.

New capillary electrophoretic method for on-line screenings of drug metabolism mediated by cytochrome P450 enzymes.

Řemínek R, Zeisbergerová M, Langmajerová M, Glatz Z.

Electrophoresis. 2013 Sep;34(18):2705-11. doi: 10.1002/elps.201300124. Epub 2013 Aug 19.

PMID:
23712309

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