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Items: 1 to 20 of 158

1.

Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants.

Andersen J, Taboureau O, Hansen KB, Olsen L, Egebjerg J, Strømgaard K, Kristensen AS.

J Biol Chem. 2009 Apr 10;284(15):10276-84. doi: 10.1074/jbc.M806907200. Epub 2009 Feb 12.

2.

Binding and orientation of tricyclic antidepressants within the central substrate site of the human serotonin transporter.

Sinning S, Musgaard M, Jensen M, Severinsen K, Celik L, Koldsø H, Meyer T, Bols M, Jensen HH, Schiøtt B, Wiborg O.

J Biol Chem. 2010 Mar 12;285(11):8363-74. doi: 10.1074/jbc.M109.045401. Epub 2009 Nov 30.

3.

Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter.

Andersen J, Olsen L, Hansen KB, Taboureau O, Jørgensen FS, Jørgensen AM, Bang-Andersen B, Egebjerg J, Strømgaard K, Kristensen AS.

J Biol Chem. 2010 Jan 15;285(3):2051-63. doi: 10.1074/jbc.M109.072587. Epub 2009 Nov 5.

7.

Molecular dynamics simulations of Na+/Cl(-)-dependent neurotransmitter transporters in a membrane-aqueous system.

Jørgensen AM, Tagmose L, Jørgensen AM, Bøgesø KP, Peters GH.

ChemMedChem. 2007 Jun;2(6):827-40.

PMID:
17436258
8.

Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants.

Henry LK, Field JR, Adkins EM, Parnas ML, Vaughan RA, Zou MF, Newman AH, Blakely RD.

J Biol Chem. 2006 Jan 27;281(4):2012-23. Epub 2005 Nov 3.

9.
10.

[Escitalopram: a selective inhibitor and allosteric modulator of the serotonin transporter].

Mnie-Filali O, El Mansari M, Scarna H, Zimmer L, Sánchez C, Haddjeri N.

Encephale. 2007 Dec;33(6):965-72. doi: 10.1016/j.encep.2007.11.001. Epub 2007 Dec 11. Review. French.

PMID:
18789789
11.

An allosteric binding site at the human serotonin transporter mediates the inhibition of escitalopram by R-citalopram: kinetic binding studies with the ALI/VFL-SI/TT mutant.

Zhong H, Hansen KB, Boyle NJ, Han K, Muske G, Huang X, Egebjerg J, Sánchez C.

Neurosci Lett. 2009 Oct 25;462(3):207-12. doi: 10.1016/j.neulet.2009.07.030. Epub 2009 Jul 16.

PMID:
19616061
12.

Non-amines, drugs without an amine nitrogen, potently block serotonin transport: novel antidepressant candidates?

Goulet M, Miller GM, Bendor J, Liu S, Meltzer PC, Madras BK.

Synapse. 2001 Dec 1;42(3):129-40.

PMID:
11746710
14.

Chimeric human and rat serotonin transporters reveal domains involved in recognition of transporter ligands.

Barker EL, Kimmel HL, Blakely RD.

Mol Pharmacol. 1994 Nov;46(5):799-807.

PMID:
7969065
15.

Allosteric effects of R- and S-citalopram on the human 5-HT transporter: evidence for distinct high- and low-affinity binding sites.

Plenge P, Gether U, Rasmussen SG.

Eur J Pharmacol. 2007 Jul 12;567(1-2):1-9. Epub 2007 Apr 14.

PMID:
17499240
16.

A single nucleotide polymorphism in the human serotonin transporter introduces a new site for N-linked glycosylation.

Rasmussen TN, Plenge P, Bay T, Egebjerg J, Gether U.

Neuropharmacology. 2009 Sep;57(3):287-94. doi: 10.1016/j.neuropharm.2009.05.009. Epub 2009 Jun 3.

PMID:
19500602
17.

Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.

Singh SK, Yamashita A, Gouaux E.

Nature. 2007 Aug 23;448(7156):952-6. Epub 2007 Aug 8.

PMID:
17687333
19.
20.

The two enantiomers of citalopram bind to the human serotonin transporter in reversed orientations.

Koldsø H, Severinsen K, Tran TT, Celik L, Jensen HH, Wiborg O, Schiøtt B, Sinning S.

J Am Chem Soc. 2010 Feb 3;132(4):1311-22. doi: 10.1021/ja906923j.

PMID:
20055463

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