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Items: 1 to 20 of 122

1.

Hypoxia-inducible factor 1 alpha under rapid enzymatic hypoxia: cells sense decrements of oxygen but not hypoxia per se.

Millonig G, Hegedüsch S, Becker L, Seitz HK, Schuppan D, Mueller S.

Free Radic Biol Med. 2009 Jan 15;46(2):182-91. doi: 10.1016/j.freeradbiomed.2008.09.043. Epub 2008 Nov 1.

PMID:
19007879
2.

Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors.

Aprelikova O, Chandramouli GV, Wood M, Vasselli JR, Riss J, Maranchie JK, Linehan WM, Barrett JC.

J Cell Biochem. 2004 Jun 1;92(3):491-501. Erratum in: J Cell Biochem. 2004 Oct 15;93(3):639.

PMID:
15156561
3.

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor.

Appelhoff RJ, Tian YM, Raval RR, Turley H, Harris AL, Pugh CW, Ratcliffe PJ, Gleadle JM.

J Biol Chem. 2004 Sep 10;279(37):38458-65. Epub 2004 Jul 7.

4.

The GOX/CAT system: a novel enzymatic method to independently control hydrogen peroxide and hypoxia in cell culture.

Mueller S, Millonig G, Waite GN.

Adv Med Sci. 2009;54(2):121-35. doi: 10.2478/v10039-009-0042-3.

PMID:
20022860
5.

PHD1 interacts with ATF4 and negatively regulates its transcriptional activity without prolyl hydroxylation.

Hiwatashi Y, Kanno K, Takasaki C, Goryo K, Sato T, Torii S, Sogawa K, Yasumoto K.

Exp Cell Res. 2011 Dec 10;317(20):2789-99. doi: 10.1016/j.yexcr.2011.09.005. Epub 2011 Sep 17.

PMID:
21951999
6.

Nitric oxide modulates oxygen sensing by hypoxia-inducible factor 1-dependent induction of prolyl hydroxylase 2.

Berchner-Pfannschmidt U, Yamac H, Trinidad B, Fandrey J.

J Biol Chem. 2007 Jan 19;282(3):1788-96. Epub 2006 Oct 23.

7.

The purpose of the HIF-1/PHD feedback loop: to limit mTOR-induced HIF-1α.

Demidenko ZN, Blagosklonny MV.

Cell Cycle. 2011 May 15;10(10):1557-62. Epub 2011 May 15.

PMID:
21521942
8.

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia.

Berra E, Benizri E, Ginouvès A, Volmat V, Roux D, Pouysségur J.

EMBO J. 2003 Aug 15;22(16):4082-90.

9.

Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors.

Henze AT, Riedel J, Diem T, Wenner J, Flamme I, Pouyseggur J, Plate KH, Acker T.

Cancer Res. 2010 Jan 1;70(1):357-66. doi: 10.1158/0008-5472.CAN-09-1876. Epub 2009 Dec 22.

10.

Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death.

Tennant DA, Frezza C, MacKenzie ED, Nguyen QD, Zheng L, Selak MA, Roberts DL, Dive C, Watson DG, Aboagye EO, Gottlieb E.

Oncogene. 2009 Nov 12;28(45):4009-21. doi: 10.1038/onc.2009.250. Epub 2009 Aug 31.

PMID:
19718054
12.

Hypoxia-inducible factors in the first trimester human lung.

Groenman F, Rutter M, Caniggia I, Tibboel D, Post M.

J Histochem Cytochem. 2007 Apr;55(4):355-63. Epub 2006 Dec 22.

PMID:
17189520
13.

Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation.

D'Angelo G, Duplan E, Boyer N, Vigne P, Frelin C.

J Biol Chem. 2003 Oct 3;278(40):38183-7. Epub 2003 Jul 21.

14.

Non-hypoxic activation of the negative regulatory feedback loop of prolyl-hydroxylase oxygen sensors.

Tug S, Delos Reyes B, Fandrey J, Berchner-Pfannschmidt U.

Biochem Biophys Res Commun. 2009 Jul 10;384(4):519-23. doi: 10.1016/j.bbrc.2009.05.016. Epub 2009 May 8.

PMID:
19427832
15.

PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis.

Ginouvès A, Ilc K, Macías N, Pouysségur J, Berra E.

Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4745-50. doi: 10.1073/pnas.0705680105. Epub 2008 Mar 17.

16.

Accumulation of hypoxia-inducible factor-1alpha is limited by transcription-dependent depletion.

Demidenko ZN, Rapisarda A, Garayoa M, Giannakakou P, Melillo G, Blagosklonny MV.

Oncogene. 2005 Jul 14;24(30):4829-38.

PMID:
15897903
17.

The regulation, localization, and functions of oxygen-sensing prolyl hydroxylase PHD3.

Jaakkola PM, Rantanen K.

Biol Chem. 2013 Apr;394(4):449-57. doi: 10.1515/hsz-2012-0330. Review.

PMID:
23380539
18.

Analysis of HIF-prolyl hydroxylases binding to substrates.

Landázuri MO, Vara-Vega A, Vitón M, Cuevas Y, del Peso L.

Biochem Biophys Res Commun. 2006 Dec 15;351(2):313-20. Epub 2006 Oct 16.

PMID:
17069766
19.

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing.

Metzen E, Berchner-Pfannschmidt U, Stengel P, Marxsen JH, Stolze I, Klinger M, Huang WQ, Wotzlaw C, Hellwig-Bürgel T, Jelkmann W, Acker H, Fandrey J.

J Cell Sci. 2003 Apr 1;116(Pt 7):1319-26.

20.

Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by hypoxia-inducible factor-1{alpha}-dependent mechanisms.

Schultz K, Murthy V, Tatro JB, Beasley D.

Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L921-7. doi: 10.1152/ajplung.90393.2008. Epub 2009 Mar 20.

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