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Items: 1 to 20 of 296

1.

Herpes simplex virus infection causes cellular beta-amyloid accumulation and secretase upregulation.

Wozniak MA, Itzhaki RF, Shipley SJ, Dobson CB.

Neurosci Lett. 2007 Dec 18;429(2-3):95-100. Epub 2007 Oct 13.

PMID:
17980964
2.

Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques.

Wozniak MA, Mee AP, Itzhaki RF.

J Pathol. 2009 Jan;217(1):131-8. doi: 10.1002/path.2449.

PMID:
18973185
3.

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics.

Roberds SL, Anderson J, Basi G, Bienkowski MJ, Branstetter DG, Chen KS, Freedman SB, Frigon NL, Games D, Hu K, Johnson-Wood K, Kappenman KE, Kawabe TT, Kola I, Kuehn R, Lee M, Liu W, Motter R, Nichols NF, Power M, Robertson DW, Schenk D, Schoor M, Shopp GM, Shuck ME, Sinha S, Svensson KA, Tatsuno G, Tintrup H, Wijsman J, Wright S, McConlogue L.

Hum Mol Genet. 2001 Jun 1;10(12):1317-24.

PMID:
11406613
4.

Vascular endothelial growth factor (VEGF) affects processing of amyloid precursor protein and beta-amyloidogenesis in brain slice cultures derived from transgenic Tg2576 mouse brain.

Bürger S, Noack M, Kirazov LP, Kirazov EP, Naydenov CL, Kouznetsova E, Yafai Y, Schliebs R.

Int J Dev Neurosci. 2009 Oct;27(6):517-23. doi: 10.1016/j.ijdevneu.2009.06.011. Epub 2009 Jul 7.

PMID:
19589380
5.
6.

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease.

Fukumoto H, Cheung BS, Hyman BT, Irizarry MC.

Arch Neurol. 2002 Sep;59(9):1381-9.

PMID:
12223024
8.

Secretion and intracellular generation of truncated Abeta in beta-site amyloid-beta precursor protein-cleaving enzyme expressing human neurons.

Lee EB, Skovronsky DM, Abtahian F, Doms RW, Lee VM.

J Biol Chem. 2003 Feb 14;278(7):4458-66. Epub 2002 Dec 11.

9.

Inhibition of Abeta production by NF-kappaB inhibitors.

Paris D, Patel N, Quadros A, Linan M, Bakshi P, Ait-Ghezala G, Mullan M.

Neurosci Lett. 2007 Mar 19;415(1):11-6. Epub 2006 Dec 27.

PMID:
17223266
10.

GEPT extract reduces Abeta deposition by regulating the balance between production and degradation of Abeta in APPV717I transgenic mice.

Tian J, Shi J, Zhang L, Yin J, Hu Q, Xu Y, Sheng S, Wang P, Ren Y, Wang R, Wang Y.

Curr Alzheimer Res. 2009 Apr;6(2):118-31.

PMID:
19355846
11.

P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.

Meredith JE Jr, Thompson LA, Toyn JH, Marcin L, Barten DM, Marcinkeviciene J, Kopcho L, Kim Y, Lin A, Guss V, Burton C, Iben L, Polson C, Cantone J, Ford M, Drexler D, Fiedler T, Lentz KA, Grace JE Jr, Kolb J, Corsa J, Pierdomenico M, Jones K, Olson RE, Macor JE, Albright CF.

J Pharmacol Exp Ther. 2008 Aug;326(2):502-13. doi: 10.1124/jpet.108.138974. Epub 2008 May 22.

12.

Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.

Sevalle J, Ayral E, Hernandez JF, Martinez J, Checler F.

J Neurochem. 2009 Jul;110(1):275-83. doi: 10.1111/j.1471-4159.2009.06131.x. Epub 2009 Apr 29.

13.

High sensitivity analysis of amyloid-beta peptide composition in amyloid deposits from human and PS2APP mouse brain.

Güntert A, Döbeli H, Bohrmann B.

Neuroscience. 2006 Dec 1;143(2):461-75. Epub 2006 Sep 27.

PMID:
17008022
14.

Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease.

Green KN, Billings LM, Roozendaal B, McGaugh JL, LaFerla FM.

J Neurosci. 2006 Aug 30;26(35):9047-56.

15.

In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.

Sankaranarayanan S, Price EA, Wu G, Crouthamel MC, Shi XP, Tugusheva K, Tyler KX, Kahana J, Ellis J, Jin L, Steele T, Stachel S, Coburn C, Simon AJ.

J Pharmacol Exp Ther. 2008 Mar;324(3):957-69. Epub 2007 Dec 21.

16.

Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease.

Yu WH, Kumar A, Peterhoff C, Shapiro Kulnane L, Uchiyama Y, Lamb BT, Cuervo AM, Nixon RA.

Int J Biochem Cell Biol. 2004 Dec;36(12):2531-40.

PMID:
15325590
17.

Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.

Brijbassi S, Amtul Z, Newbigging S, Westaway D, St George-Hyslop P, Rozmahel RF.

Neurobiol Dis. 2007 Feb;25(2):291-6. Epub 2006 Oct 27.

PMID:
17071095
18.

Age-dependent differential expression of BACE splice variants in brain regions of tg2576 mice.

Zohar O, Pick CG, Cavallaro S, Chapman J, Katzav A, Milman A, Alkon DL.

Neurobiol Aging. 2005 Aug-Sep;26(8):1167-75. Epub 2005 Jan 7.

PMID:
15917100
19.

Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease.

Kumar-Singh S, De Jonghe C, Cruts M, Kleinert R, Wang R, Mercken M, De Strooper B, Vanderstichele H, Löfgren A, Vanderhoeven I, Backhovens H, Vanmechelen E, Kroisel PM, Van Broeckhoven C.

Hum Mol Genet. 2000 Nov 1;9(18):2589-98.

PMID:
11063718

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