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Items: 1 to 20 of 109


Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages.

Seimon TA, Obstfeld A, Moore KJ, Golenbock DT, Tabas I.

Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19794-9. Epub 2006 Dec 13.


Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor.

Devries-Seimon T, Li Y, Yao PM, Stone E, Wang Y, Davis RJ, Flavell R, Tabas I.

J Cell Biol. 2005 Oct 10;171(1):61-73. Epub 2005 Oct 3.


Free cholesterol-induced macrophage apoptosis is mediated by inositol-requiring enzyme 1 alpha-regulated activation of Jun N-terminal kinase.

Li F, Guo Y, Sun S, Jiang X, Tang B, Wang Q, Wang L.

Acta Biochim Biophys Sin (Shanghai). 2008 Mar;40(3):226-34.


The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol.

Byrd-Leifer CA, Block EF, Takeda K, Akira S, Ding A.

Eur J Immunol. 2001 Aug;31(8):2448-57.


Signal transducer and activator of transcription-1 is critical for apoptosis in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced atherosclerotic lesions in vivo.

Lim WS, Timmins JM, Seimon TA, Sadler A, Kolodgie FD, Virmani R, Tabas I.

Circulation. 2008 Feb 19;117(7):940-51. doi: 10.1161/CIRCULATIONAHA.107.711275. Epub 2008 Jan 28. Erratum in: Circulation. 2008 Apr 1;117(13):e303.


Lipopolysaccharide of Aggregatibacter actinomycetemcomitans induces the expression of chemokines MCP-1, MIP-1α, and IP-10 via similar but distinct signaling pathways in murine macrophages.

Park OJ, Cho MK, Yun CH, Han SH.

Immunobiology. 2015 Sep;220(9):1067-74. doi: 10.1016/j.imbio.2015.05.008. Epub 2015 May 11.


Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway.

Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S.

Science. 2003 Aug 1;301(5633):640-3. Epub 2003 Jul 10.


The impact of insulin resistance on macrophage death pathways in advanced atherosclerosis.

Tabas I, Seimon T, Arellano J, Li Y, Forcheron F, Cui D, Han S, Liang CP, Tall A, Accili D.

Novartis Found Symp. 2007;286:99-109; discussion 109-12, 162-3, 196-203.


CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance.

Rajaiah R, Perkins DJ, Ireland DD, Vogel SN.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8391-6. doi: 10.1073/pnas.1424980112. Epub 2015 Jun 23.


A requirement for the p85 PI3K adapter protein BCAP in the protection of macrophages from apoptosis induced by endoplasmic reticulum stress.

Song S, Chew C, Dale BM, Traum D, Peacock J, Yamazaki T, Clynes R, Kurosaki T, Greenberg S.

J Immunol. 2011 Jul 15;187(2):619-25. doi: 10.4049/jimmunol.0903425. Epub 2011 Jun 17.


Pattern recognition scavenger receptor CD204 attenuates Toll-like receptor 4-induced NF-kappaB activation by directly inhibiting ubiquitination of tumor necrosis factor (TNF) receptor-associated factor 6.

Yu X, Yi H, Guo C, Zuo D, Wang Y, Kim HL, Subjeck JR, Wang XY.

J Biol Chem. 2011 May 27;286(21):18795-806. doi: 10.1074/jbc.M111.224345. Epub 2011 Apr 1.


TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: a critical role of IFN-beta as a decision maker.

Jung DY, Lee H, Jung BY, Ock J, Lee MS, Lee WH, Suk K.

J Immunol. 2005 May 15;174(10):6467-76.


Toll-like receptor 4 mediates the antitumor host response induced by a 55-kilodalton protein isolated from Aeginetia indica L., a parasitic plant.

Okamoto M, Oh-E G, Oshikawa T, Furuichi S, Tano T, Ahmed SU, Akashi S, Miyake K, Takeuchi O, Akira S, Himeno K, Sato M, Ohkubo S.

Clin Diagn Lab Immunol. 2004 May;11(3):483-95.


PKR regulates TLR2/TLR4-dependent signaling in murine alveolar macrophages.

Cabanski M, Steinmüller M, Marsh LM, Surdziel E, Seeger W, Lohmeyer J.

Am J Respir Cell Mol Biol. 2008 Jan;38(1):26-31. Epub 2007 Aug 9.


The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4.

Hsu LC, Park JM, Zhang K, Luo JL, Maeda S, Kaufman RJ, Eckmann L, Guiney DG, Karin M.

Nature. 2004 Mar 18;428(6980):341-5.


Calcineurin negatively regulates TLR-mediated activation pathways.

Kang YJ, Kusler B, Otsuka M, Hughes M, Suzuki N, Suzuki S, Yeh WC, Akira S, Han J, Jones PP.

J Immunol. 2007 Oct 1;179(7):4598-607.


Calcium/calmodulin-dependent kinase II is required for platelet-activating factor priming.

Cuschieri J, Bulger E, Garcia I, Jelacic S, Maier RV.

Shock. 2005 Feb;23(2):99-106.


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