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Items: 1 to 20 of 393

2.

Reduction of iron-regulated amyloid precursor protein and beta-amyloid peptide by (-)-epigallocatechin-3-gallate in cell cultures: implications for iron chelation in Alzheimer's disease.

Reznichenko L, Amit T, Zheng H, Avramovich-Tirosh Y, Youdim MB, Weinreb O, Mandel S.

J Neurochem. 2006 Apr;97(2):527-36. Epub 2006 Mar 15.

4.

Oxidative stress promotes JNK-dependent amyloidogenic processing of normally expressed human APP by differential modification of alpha-, beta- and gamma-secretase expression.

Quiroz-Baez R, Rojas E, Arias C.

Neurochem Int. 2009 Dec;55(7):662-70. doi: 10.1016/j.neuint.2009.06.012. Epub 2009 Jun 26.

PMID:
19560504
5.

L-theanine protects the APP (Swedish mutation) transgenic SH-SY5Y cell against glutamate-induced excitotoxicity via inhibition of the NMDA receptor pathway.

Di X, Yan J, Zhao Y, Zhang J, Shi Z, Chang Y, Zhao B.

Neuroscience. 2010 Jul 14;168(3):778-86. doi: 10.1016/j.neuroscience.2010.04.019. Epub 2010 Apr 21.

PMID:
20416364
6.

Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells.

Peng Y, Jiang L, Lee DY, Schachter SC, Ma Z, Lemere CA.

J Neurosci Res. 2006 Sep;84(4):903-11.

PMID:
16862548
8.

Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron- chelating- antioxidants, M-30 and green tea polyphenol, EGCG.

Avramovich-Tirosh Y, Reznichenko L, Mit T, Zheng H, Fridkin M, Weinreb O, Mandel S, Youdim MB.

Curr Alzheimer Res. 2007 Sep;4(4):403-11.

PMID:
17908043
9.

β-Amyloid peptide increases levels of iron content and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease.

Wan L, Nie G, Zhang J, Luo Y, Zhang P, Zhang Z, Zhao B.

Free Radic Biol Med. 2011 Jan 1;50(1):122-9. doi: 10.1016/j.freeradbiomed.2010.10.707. Epub 2010 Oct 26.

PMID:
21034809
10.
11.
12.

Inhibition of gamma-secretase activity reduces Abeta production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer's disease.

Sheng B, Gong K, Niu Y, Liu L, Yan Y, Lu G, Zhang L, Hu M, Zhao N, Zhang X, Tang P, Gong Y.

Free Radic Biol Med. 2009 May 15;46(10):1362-75. doi: 10.1016/j.freeradbiomed.2009.02.018. Epub 2009 Mar 3.

PMID:
19264123
14.

Divalent metal transporter 1 is involved in amyloid precursor protein processing and Abeta generation.

Zheng W, Xin N, Chi ZH, Zhao BL, Zhang J, Li JY, Wang ZY.

FASEB J. 2009 Dec;23(12):4207-17. doi: 10.1096/fj.09-135749. Epub 2009 Aug 13.

PMID:
19679638
15.

Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene.

Wang PL, Niidome T, Akaike A, Kihara T, Sugimoto H.

J Neurosci Res. 2009 Jul;87(9):2105-14. doi: 10.1002/jnr.22039.

PMID:
19267423
16.

Protective effect of pyrroloquinoline quinone against Abeta-induced neurotoxicity in human neuroblastoma SH-SY5Y cells.

Zhang JJ, Zhang RF, Meng XK.

Neurosci Lett. 2009 Oct 30;464(3):165-9. doi: 10.1016/j.neulet.2009.08.037. Epub 2009 Aug 20.

PMID:
19699263
17.

Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).

Kuzuya A, Uemura K, Kitagawa N, Aoyagi N, Kihara T, Ninomiya H, Ishiura S, Takahashi R, Shimohama S.

J Neurosci Res. 2007 Jan;85(1):153-65.

PMID:
17075903
18.

Amyloid precursor protein and amyloid beta-peptide bind to ATP synthase and regulate its activity at the surface of neural cells.

Schmidt C, Lepsverdize E, Chi SL, Das AM, Pizzo SV, Dityatev A, Schachner M.

Mol Psychiatry. 2008 Oct;13(10):953-69. Epub 2007 Aug 28.

PMID:
17726461
19.

BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice.

Nishitomi K, Sakaguchi G, Horikoshi Y, Gray AJ, Maeda M, Hirata-Fukae C, Becker AG, Hosono M, Sakaguchi I, Minami SS, Nakajima Y, Li HF, Takeyama C, Kihara T, Ota A, Wong PC, Aisen PS, Kato A, Kinoshita N, Matsuoka Y.

J Neurochem. 2006 Dec;99(6):1555-63. Epub 2006 Nov 2.

20.

Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates Alzheimer's disease-related neuropathies: involvement of non-amyloidogenic processing.

Hwang SH, Shin EJ, Shin TJ, Lee BH, Choi SH, Kang J, Kim HJ, Kwon SH, Jang CG, Lee JH, Kim HC, Nah SY.

J Alzheimers Dis. 2012;31(1):207-23. doi: 10.3233/JAD-2012-120439.

PMID:
22543851

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