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Items: 1 to 20 of 117

1.

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease.

Cohen JC, Boerwinkle E, Mosley TH Jr, Hobbs HH.

N Engl J Med. 2006 Mar 23;354(12):1264-72.

2.

Molecular biology of PCSK9: its role in LDL metabolism.

Horton JD, Cohen JC, Hobbs HH.

Trends Biochem Sci. 2007 Feb;32(2):71-7. Epub 2007 Jan 9. Review.

3.

PCSK9 Loss-of-Function Variants, Low-Density Lipoprotein Cholesterol, and Risk of Coronary Heart Disease and Stroke: Data From 9 Studies of Blacks and Whites.

Kent ST, Rosenson RS, Avery CL, Chen YI, Correa A, Cummings SR, Cupples LA, Cushman M, Evans DS, Gudnason V, Harris TB, Howard G, Irvin MR, Judd SE, Jukema JW, Lange L, Levitan EB, Li X, Liu Y, Post WS, Postmus I, Psaty BM, Rotter JI, Safford MM, Sitlani CM, Smith AV, Stewart JD, Trompet S, Sun F, Vasan RS, Woolley JM, Whitsel EA, Wiggins KL, Wilson JG, Muntner P.

Circ Cardiovasc Genet. 2017 Aug;10(4):e001632. doi: 10.1161/CIRCGENETICS.116.001632.

PMID:
28768753
4.

Sequence variation in proprotein convertase subtilisin/kexin type 9 serine protease gene, low LDL cholesterol, and cancer incidence.

Folsom AR, Peacock JM, Boerwinkle E.

Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2455-8.

5.

The PCSK9 gene R46L variant is associated with lower plasma lipid levels and cardiovascular risk in healthy U.K. men.

Scartezini M, Hubbart C, Whittall RA, Cooper JA, Neil AH, Humphries SE.

Clin Sci (Lond). 2007 Dec;113(11):435-41.

PMID:
17550346
6.

Protease variants, LDL, and coronary heart disease.

Tall AR.

N Engl J Med. 2006 Mar 23;354(12):1310-2. No abstract available.

PMID:
16554535
7.

Relation of PCSK9 mutations to serum low-density lipoprotein cholesterol in childhood and adulthood (from The Bogalusa Heart Study).

Hallman DM, Srinivasan SR, Chen W, Boerwinkle E, Berenson GS.

Am J Cardiol. 2007 Jul 1;100(1):69-72. Epub 2007 May 11.

PMID:
17599443
8.

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

Cohen J, Pertsemlidis A, Kotowski IK, Graham R, Garcia CK, Hobbs HH.

Nat Genet. 2005 Feb;37(2):161-5. Epub 2005 Jan 16. Erratum in: Nat Genet. 2005 Mar;37(3):328.

PMID:
15654334
9.

A novel loss of function mutation of PCSK9 gene in white subjects with low-plasma low-density lipoprotein cholesterol.

Fasano T, Cefalù AB, Di Leo E, Noto D, Pollaccia D, Bocchi L, Valenti V, Bonardi R, Guardamagna O, Averna M, Tarugi P.

Arterioscler Thromb Vasc Biol. 2007 Mar;27(3):677-81. Epub 2006 Dec 14.

10.

Ethnic differences in the frequency of the cardioprotective C679X PCSK9 mutation in a West African population.

Sirois F, Gbeha E, Sanni A, Chretien M, Labuda D, Mbikay M.

Genet Test. 2008 Sep;12(3):377-80. doi: 10.1089/gte.2008.0013.

PMID:
18652535
11.
12.

Effects of PCSK9 genetic variants on plasma LDL cholesterol levels and risk of premature myocardial infarction in the Italian population.

Guella I, Asselta R, Ardissino D, Merlini PA, Peyvandi F, Kathiresan S, Mannucci PM, Tubaro M, Duga S.

J Lipid Res. 2010 Nov;51(11):3342-9. doi: 10.1194/jlr.M010009. Epub 2010 Aug 10.

14.

Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.

Peloso GM, Auer PL, Bis JC, Voorman A, Morrison AC, Stitziel NO, Brody JA, Khetarpal SA, Crosby JR, Fornage M, Isaacs A, Jakobsdottir J, Feitosa MF, Davies G, Huffman JE, Manichaikul A, Davis B, Lohman K, Joon AY, Smith AV, Grove ML, Zanoni P, Redon V, Demissie S, Lawson K, Peters U, Carlson C, Jackson RD, Ryckman KK, Mackey RH, Robinson JG, Siscovick DS, Schreiner PJ, Mychaleckyj JC, Pankow JS, Hofman A, Uitterlinden AG, Harris TB, Taylor KD, Stafford JM, Reynolds LM, Marioni RE, Dehghan A, Franco OH, Patel AP, Lu Y, Hindy G, Gottesman O, Bottinger EP, Melander O, Orho-Melander M, Loos RJ, Duga S, Merlini PA, Farrall M, Goel A, Asselta R, Girelli D, Martinelli N, Shah SH, Kraus WE, Li M, Rader DJ, Reilly MP, McPherson R, Watkins H, Ardissino D; NHLBI GO Exome Sequencing Project, Zhang Q, Wang J, Tsai MY, Taylor HA, Correa A, Griswold ME, Lange LA, Starr JM, Rudan I, Eiriksdottir G, Launer LJ, Ordovas JM, Levy D, Chen YD, Reiner AP, Hayward C, Polasek O, Deary IJ, Borecki IB, Liu Y, Gudnason V, Wilson JG, van Duijn CM, Kooperberg C, Rich SS, Psaty BM, Rotter JI, O'Donnell CJ, Rice K, Boerwinkle E, Kathiresan S, Cupples LA.

Am J Hum Genet. 2014 Feb 6;94(2):223-32. doi: 10.1016/j.ajhg.2014.01.009.

15.

PCSK9 gene mutations and low-density lipoprotein cholesterol.

Wu NQ, Li JJ.

Clin Chim Acta. 2014 Apr 20;431:148-53. doi: 10.1016/j.cca.2014.01.043. Epub 2014 Feb 8. Review.

PMID:
24518357
16.

The C679X mutation in PCSK9 is present and lowers blood cholesterol in a Southern African population.

Hooper AJ, Marais AD, Tanyanyiwa DM, Burnett JR.

Atherosclerosis. 2007 Aug;193(2):445-8. Epub 2006 Sep 20.

PMID:
16989838
17.

G-protein estrogen receptor as a regulator of low-density lipoprotein cholesterol metabolism: cellular and population genetic studies.

Hussain Y, Ding Q, Connelly PW, Brunt JH, Ban MR, McIntyre AD, Huff MW, Gros R, Hegele RA, Feldman RD.

Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):213-21. doi: 10.1161/ATVBAHA.114.304326. Epub 2014 Nov 13.

18.

Low-density lipoprotein cholesterol and the risk of cancer: a mendelian randomization study.

Benn M, Tybjærg-Hansen A, Stender S, Frikke-Schmidt R, Nordestgaard BG.

J Natl Cancer Inst. 2011 Mar 16;103(6):508-19. doi: 10.1093/jnci/djr008. Epub 2011 Feb 1.

PMID:
21285406
19.

A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol.

Kotowski IK, Pertsemlidis A, Luke A, Cooper RS, Vega GL, Cohen JC, Hobbs HH.

Am J Hum Genet. 2006 Mar;78(3):410-22. Epub 2006 Jan 20.

20.

Proprotein convertase subtilisin/kexin type 9 gene E670G polymorphism interacts with alcohol consumption to modulate serum lipid levels.

Aung LH, Yin RX, Wu DF, Cao XL, Hu XJ, Miao L.

Int J Med Sci. 2013;10(2):124-32. doi: 10.7150/ijms.5296. Epub 2012 Dec 30.

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