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Items: 1 to 20 of 230

1.

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases.

Opresko PL, von Kobbe C, Laine JP, Harrigan J, Hickson ID, Bohr VA.

J Biol Chem. 2002 Oct 25;277(43):41110-9. Epub 2002 Aug 13.

2.

POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates.

Opresko PL, Mason PA, Podell ER, Lei M, Hickson ID, Cech TR, Bohr VA.

J Biol Chem. 2005 Sep 16;280(37):32069-80. Epub 2005 Jul 18.

3.

The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2.

Opresko PL, Otterlei M, Graakjaer J, Bruheim P, Dawut L, Kølvraa S, May A, Seidman MM, Bohr VA.

Mol Cell. 2004 Jun 18;14(6):763-74.

4.

TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA.

Machwe A, Xiao L, Orren DK.

Oncogene. 2004 Jan 8;23(1):149-56.

PMID:
14712220
5.
6.

Werner protein protects nonproliferating cells from oxidative DNA damage.

Szekely AM, Bleichert F, Nümann A, Van Komen S, Manasanch E, Ben Nasr A, Canaan A, Weissman SM.

Mol Cell Biol. 2005 Dec;25(23):10492-506.

7.

Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2.

Lillard-Wetherell K, Machwe A, Langland GT, Combs KA, Behbehani GK, Schonberg SA, German J, Turchi JJ, Orren DK, Groden J.

Hum Mol Genet. 2004 Sep 1;13(17):1919-32. Epub 2004 Jun 30.

PMID:
15229185
8.

Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase.

Nora GJ, Buncher NA, Opresko PL.

Nucleic Acids Res. 2010 Jul;38(12):3984-98. doi: 10.1093/nar/gkq144. Epub 2010 Mar 9.

9.

Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases.

Doherty KM, Sommers JA, Gray MD, Lee JW, von Kobbe C, Thoma NH, Kureekattil RP, Kenny MK, Brosh RM Jr.

J Biol Chem. 2005 Aug 19;280(33):29494-505. Epub 2005 Jun 17.

10.

WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening.

Li B, Jog SP, Reddy S, Comai L.

Mol Cell Biol. 2008 Mar;28(6):1892-904. doi: 10.1128/MCB.01364-07. Epub 2008 Jan 22.

11.

Human RECQL1 participates in telomere maintenance.

Popuri V, Hsu J, Khadka P, Horvath K, Liu Y, Croteau DL, Bohr VA.

Nucleic Acids Res. 2014 May;42(9):5671-88. doi: 10.1093/nar/gku200. Epub 2014 Mar 12. Erratum in: Nucleic Acids Res. 2017 Mar 17;45(5):2935.

12.
13.

Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2.

Edwards DN, Orren DK, Machwe A.

Nucleic Acids Res. 2014 Jul;42(12):7748-61. doi: 10.1093/nar/gku454. Epub 2014 May 31.

14.

The Bloom syndrome helicase BLM interacts with TRF2 in ALT cells and promotes telomeric DNA synthesis.

Stavropoulos DJ, Bradshaw PS, Li X, Pasic I, Truong K, Ikura M, Ungrin M, Meyn MS.

Hum Mol Genet. 2002 Dec 1;11(25):3135-44.

PMID:
12444098
15.

In vivo function of the conserved non-catalytic domain of Werner syndrome helicase in DNA replication.

Sharma S, Sommers JA, Brosh RM Jr.

Hum Mol Genet. 2004 Oct 1;13(19):2247-61. Epub 2004 Jul 28.

PMID:
15282207
16.

The Werner and Bloom syndrome proteins catalyze regression of a model replication fork.

Machwe A, Xiao L, Groden J, Orren DK.

Biochemistry. 2006 Nov 28;45(47):13939-46.

PMID:
17115688
17.

Enzymatic mechanism of the WRN helicase/nuclease.

Brosh RM Jr, Opresko PL, Bohr VA.

Methods Enzymol. 2006;409:52-85.

PMID:
16793395
18.

Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins.

von Kobbe C, Karmakar P, Dawut L, Opresko P, Zeng X, Brosh RM Jr, Hickson ID, Bohr VA.

J Biol Chem. 2002 Jun 14;277(24):22035-44. Epub 2002 Mar 27.

19.

The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro.

Orren DK, Theodore S, Machwe A.

Biochemistry. 2002 Nov 19;41(46):13483-8.

PMID:
12427008
20.

Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs.

Brosh RM Jr, Karow JK, White EJ, Shaw ND, Hickson ID, Bohr VA.

Nucleic Acids Res. 2000 Jun 15;28(12):2420-30.

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