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Acute doses of caffeine shift nervous system cell expression profiles toward promotion of neuronal projection growth.
Yu NY, Bieder A, Raman A, Mileti E, Katayama S, Einarsdottir E, Fredholm BB, Falk A, Tapia-Páez I, Daub CO, Kere J.
Sci Rep. 2017 Sep 13;7(1):11458. doi: 10.1038/s41598-017-11574-6.
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Lazarus M, Chen JF, Huang ZL, Urade Y, Fredholm BB.
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Adenosine - from molecular mechanisms to pathophysiology.
Sobrevia L, Fredholm BB.
Mol Aspects Med. 2017 Jun;55:1-3. doi: 10.1016/j.mam.2017.06.003. Epub 2017 Jun 17. No abstract available.
Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia.
Winerdal M, Urmaliya V, Winerdal ME, Fredholm BB, Winqvist O, Ådén U.
PLoS One. 2017 Jan 27;12(1):e0170545. doi: 10.1371/journal.pone.0170545. eCollection 2017.
Pharmacological targeting of adenosine receptor signaling.
Peleli M, Fredholm BB, Sobrevia L, Carlström M.
Mol Aspects Med. 2017 Jun;55:4-8. doi: 10.1016/j.mam.2016.12.002. Epub 2017 Jan 12. Review.
Low, but not high, dose caffeine is a readily available probe for adenosine actions.
Fredholm BB, Yang J, Wang Y.
Mol Aspects Med. 2017 Jun;55:20-25. doi: 10.1016/j.mam.2016.11.011. Epub 2016 Nov 30. Review.
Genetic Abrogation of Adenosine A3 Receptor Prevents Uninephrectomy and High Salt-Induced Hypertension.
Yang T, Zollbrecht C, Winerdal ME, Zhuge Z, Zhang XM, Terrando N, Checa A, Sällström J, Wheelock CE, Winqvist O, Harris RA, Larsson E, Persson AE, Fredholm BB, Carlström M.
J Am Heart Assoc. 2016 Jul 18;5(7). pii: e003868. doi: 10.1161/JAHA.116.003868.
Adenosine A1 receptors contribute to immune regulation after neonatal hypoxic ischemic brain injury.
Winerdal M, Winerdal ME, Wang YQ, Fredholm BB, Winqvist O, Ådén U.
Purinergic Signal. 2016 Mar;12(1):89-101. doi: 10.1007/s11302-015-9482-3. Epub 2015 Nov 25.
In adenosine A2B knockouts acute treatment with inorganic nitrate improves glucose disposal, oxidative stress, and AMPK signaling in the liver.
Peleli M, Hezel M, Zollbrecht C, Persson AE, Lundberg JO, Weitzberg E, Fredholm BB, Carlström M.
Front Physiol. 2015 Aug 7;6:222. doi: 10.3389/fphys.2015.00222. eCollection 2015.
Abrogation of adenosine A1 receptor signalling improves metabolic regulation in mice by modulating oxidative stress and inflammatory responses.
Yang T, Gao X, Sandberg M, Zollbrecht C, Zhang XM, Hezel M, Liu M, Peleli M, Lai EY, Harris RA, Persson AE, Fredholm BB, Jansson L, Carlström M.
Diabetologia. 2015 Jul;58(7):1610-20. doi: 10.1007/s00125-015-3570-3. Epub 2015 Apr 3.
Adenosine--a physiological or pathophysiological agent?
Fredholm BB.
J Mol Med (Berl). 2014 Mar;92(3):201-6. doi: 10.1007/s00109-013-1101-6. Epub 2013 Dec 22. Review.
Adenosine increases LPS-induced nuclear factor kappa B activation in smooth muscle cells via an intracellular mechanism and modulates it via actions on adenosine receptors.
Yang J, Zheng X, Haugen F, Darè E, Lövdahl C, Schulte G, Fredholm BB, Valen G.
Acta Physiol (Oxf). 2014 Mar;210(3):590-9. doi: 10.1111/apha.12176. Epub 2013 Oct 28.
Inhibition of sodium-linked glucose reabsorption normalizes diabetes-induced glomerular hyperfiltration in conscious adenosine A₁-receptor deficient mice.
Sällström J, Eriksson T, Fredholm BB, Persson AE, Palm F.
Acta Physiol (Oxf). 2014 Feb;210(2):440-5. doi: 10.1111/apha.12152. Epub 2013 Aug 27.
Adenosine receptors as drug targets--what are the challenges?
Chen JF, Eltzschig HK, Fredholm BB.
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[The Nobel Prize to detailed studies of G protein-coupled receptors. This years Nobel Prize in chemistry provides important knowledge--but it might take a while before it can be practically applied].
Lakartidningen. 2012 Dec;109(49-50):2274-5. Swedish. No abstract available.
Improved blood glucose disposal and altered insulin secretion patterns in adenosine A(1) receptor knockout mice.
Yang GK, Fredholm BB, Kieffer TJ, Kwok YN.
Am J Physiol Endocrinol Metab. 2012 Jul 15;303(2):E180-90. doi: 10.1152/ajpendo.00050.2012. Epub 2012 May 1.
Rethinking the purinergic neuron-glia connection.
Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):5913-4. doi: 10.1073/pnas.1203764109. Epub 2012 Apr 16. No abstract available.
CX3CL1 is neuroprotective in permanent focal cerebral ischemia in rodents.
Cipriani R, Villa P, Chece G, Lauro C, Paladini A, Micotti E, Perego C, De Simoni MG, Fredholm BB, Eusebi F, Limatola C.
J Neurosci. 2011 Nov 9;31(45):16327-35. doi: 10.1523/JNEUROSCI.3611-11.2011.
Adenosine A₁-receptor deficiency diminishes afferent arteriolar and blood pressure responses during nitric oxide inhibition and angiotensin II treatment.
Gao X, Patzak A, Sendeski M, Scheffer PG, Teerlink T, Sällström J, Fredholm BB, Persson AE, Carlström M.
Am J Physiol Regul Integr Comp Physiol. 2011 Dec;301(6):R1669-81. doi: 10.1152/ajpregu.00268.2011. Epub 2011 Oct 5.
Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens.
Lazarus M, Shen HY, Cherasse Y, Qu WM, Huang ZL, Bass CE, Winsky-Sommerer R, Semba K, Fredholm BB, Boison D, Hayaishi O, Urade Y, Chen JF.
J Neurosci. 2011 Jul 6;31(27):10067-75. doi: 10.1523/JNEUROSCI.6730-10.2011.
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