Fine mapping in the region 128.47–128.54 Mb of 8q24. We present data for 82 SNPs that we genotyped in 1,088 individuals with CRC and 1,823 controls. These SNPs capture ≥92% of SNPs of >5% minor allele frequency at r2 > 0.8 in HapMap populations (). (a) The most strongly associated SNP is rs10808556 (red), P = 2.2 × 10−6, which is substantially more associated than rs6983267 (green), the SNP that initially led us to the region (P = 2.4 × 10−4). (b) Controlling for rs10808556 in a logistic regression analysis, no SNP is significant at P < 0.05 after correcting for 82 hypotheses tested (threshold shown by a light gray line).