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Int J Biol Macromol. 2018 Jul 1;113:51-58. doi: 10.1016/j.ijbiomac.2018.02.096. Epub 2018 Feb 19.

Facile, green and scalable method to produce carrageenan-based hydrogel containing in situ synthesized AgNPs for application as wound dressing.

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Pós-Graduação em Ciências da Saúde, Universidade do Sul de Santa Catarina, 88701-000 Tubarão, SC, Brazil. Electronic address:
Pós-Graduação em Ciências da Saúde, Universidade do Sul de Santa Catarina, 88701-000 Tubarão, SC, Brazil.
Pós-Graduação em Ciência e Engenharia de Materiais, Universidade Federal do Amazonas, 69077-000 Manaus, AM, Brazil.
Pós-Graduação em Tecnologia de Materiais e Processos Industriais, Universidade Feevale, 93525-075 Novo Hamburgo, RS, Brazil.


This manuscript was focused on introducing a facile, green and scalable method to produce kappa-carrageenan (κC) hydrogel membranes containing in situ synthesized silver nanoparticles (AgNPs). In a typical protocol, κC hydrogels were obtained by heating (sol phase), followed by cooling (gel phase) the polysaccharide solution, which enabled the simultaneous synthesis of AgNPs during the heating time. The as synthesized AgNPs were characterized spectrophotometrically, and by dynamic light scattering and transmission electron microscopy. The swelling properties at different pH and the antimicrobial activity of κC-AgNP hydrogel were investigated. AgNPs were mostly spherical in shape, crystalline in nature and measuring ca. 27nm in diameter. The in situ synthesis of AgNPs changed the swelling properties of κC hydrogel and also reduces its viscosity and gelling temperature. The AgNPs were continuously released from κC hydrogel for up to 48h in a concentration sufficient to prevent the bacterial growth as confirmed by antimicrobial tests. The simplicity involved in the AgNPs synthesis combined to the good spreadability of κC hydrogel makes this method suitable for scale-up to manufacturing quantities of wound dressing.


Green synthesis; Silver nanoparticles; Wound dressing

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