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1.
Tissue Eng. 2002 Feb;8(1):1-11.

The design of scaffolds for use in tissue engineering. Part II. Rapid prototyping techniques.

Author information

1
Design Research Center, School of Mechanical and Production Engineering, Nanyang Technological University, Singapore.

Abstract

Tissue engineering (TE) is an important emerging area in biomedical engineering for creating biological alternatives for harvested tissues, implants, and prostheses. In TE, a highly porous artificial extracellular matrix or scaffold is required to accommodate mammalian cells and guide their growth and tissue regeneration in three-dimension (3D). However, existing 3D scaffolds for TE proved less than ideal for actual applications because they lack mechanical strength, interconnected channels, and controlled porosity or pores distribution. In this paper, the authors review the application and advancement of rapid prototyping (RP) techniques in the design and creation of synthetic scaffolds for use in TE. We also review the advantages and benefits, and limitations and shortcomings of current RP techniques as well as the future direction of RP development in TE scaffold fabrication.

PMID:
11886649
DOI:
10.1089/107632702753503009
[Indexed for MEDLINE]
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2.
Tissue Eng. 2001 Dec;7(6):679-89.

The design of scaffolds for use in tissue engineering. Part I. Traditional factors.

Author information

1
Design Research Center, School of Mechanical and Production Engineering, Nanyang Technological University, Singapore.

Abstract

In tissue engineering, a highly porous artificial extracellular matrix or scaffold is required to accommodate mammalian cells and guide their growth and tissue regeneration in three dimensions. However, existing three-dimensional scaffolds for tissue engineering proved less than ideal for actual applications, not only because they lack mechanical strength, but they also do not guarantee interconnected channels. In this paper, the authors analyze the factors necessary to enhance the design and manufacture of scaffolds for use in tissue engineering in terms of materials, structure, and mechanical properties and review the traditional scaffold fabrication methods. Advantages and limitations of these traditional methods are also discussed.

PMID:
11749726
DOI:
10.1089/107632701753337645
[Indexed for MEDLINE]
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