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J Neurol Sci. 2016 Sep 15;368:121-7. doi: 10.1016/j.jns.2016.06.071. Epub 2016 Jul 4.

Role of galectin-3 in plasma as a predictive biomarker of outcome after acute intracerebral hemorrhage.

Author information

1
Department of Neurosurgery, Quzhou People's Hospital, 2 Zhongloudi Road, Kecheng District, Quzhou 324100, China.
2
Department of Neurosurgery, Quzhou People's Hospital, 2 Zhongloudi Road, Kecheng District, Quzhou 324100, China. Electronic address: uanuenuau@163.com.

Abstract

OBJECTIVE:

Inflammation is involved in pathophysiological mechanisms underlying secondary brain injury after intracerebral hemorrhage. Enhanced circulating levels of galectin-3, a proinflammatory cytokine, have close relation to poor prognosis of some inflammatory illnesses. This study was designed to investigate whether plasma galectin-3 levels are related to the inflammation, severity and prognosis following intracerebral hemorrhage.

METHODS:

In this observational, prospective study, plasma galectin-3 levels of 110 patients and 110 controls were determined. We further assessed the association of galectin-3 levels with inflammation reflected by systemic C-reactive protein levels, severity indicated by hematoma volumes and National Institutes of Health Stroke Scale (NIHSS) scores, and endpoints including 1-week mortality, 6-month mortality, 6-month overall survival and 6-month unfavorable outcome (modified Rankin Scale score>2).

RESULTS:

Plasma galectin-3 levels of patients were significantly higher than those of controls. Galectin-3 was identified as an independent prognostic predictor for 1-week mortality, 6-month mortality, 6-month overall survival and 6-month unfavorable outcome, as well as had strong relation to C-reactive protein levels, hematoma volumes and NIHSS scores. Compared with NIHSS scores and hematoma volumes, plasma galectin-3 levels had similar areas under receiver operating characteristic curve (AUC). Moreover, galectin-3 levels significantly improved AUCs of NIHSS scores or hematoma volumes alone for prediction of 6-month mortality and 6-month unfavorable outcome.

CONCLUSIONS:

Elevated plasma galectin-3 levels are strongly associated with the inflammation, severity and poor prognosis after intracerebral hemorrhage, indicating galectin-3, involved in brain inflammation, might have the potential to be a prognostic biomarker for hemorrhagic stroke.

KEYWORDS:

Galectin-3; Inflammation; Intracerebral hemorrhage; Prognosis; Severity

PMID:
27538613
DOI:
10.1016/j.jns.2016.06.071
[Indexed for MEDLINE]

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