Format

Send to

Choose Destination
  • Filters activated: Field: Title Word. Clear all
Colloids Surf B Biointerfaces. 2018 Mar 1;163:100-106. doi: 10.1016/j.colsurfb.2017.12.032. Epub 2017 Dec 19.

Optimized polymer coating for magnesium alloy-based bioresorbable scaffolds for long-lasting drug release and corrosion resistance.

Author information

1
Faculty of Advanced Science and Technology, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto 860-8555, Japan.
2
Japan Medical Device Technology Co., Ltd., 2020-3 Tahara, Mashiki-machi, Kumamoto 861-2202, Japan.
3
Japan Medical Device Technology Co., Ltd., 2020-3 Tahara, Mashiki-machi, Kumamoto 861-2202, Japan. Electronic address: m.sasaki@jmdt.co.jp.
4
Faculty of Advanced Science and Technology, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto 860-8555, Japan. Electronic address: niidome@kumamoto-u.ac.jp.

Abstract

Magnesium (Mg) alloy-based bioresorbable scaffolds (BRSs) are attracting interest as next-generation stents. However, because medical Mg alloy materials degrade relatively quickly in physiological media, surface corrosion protection via biodegradable polymer coatings is important for clinical applications. Herein, the influence of biodegradable polymer coatings on the BRS corrosion was investigated. First, elution of the drug sirolimus (SRL) from various biodegradable polymers was estimated, including poly(d,l-lactic acid) (PDLLA), poly(d,l-lactic acid-co-ε-caprolactone) (PLCL) and poly(ε-caprolactone) (PCL). Among these, the PDLLA polymer exhibited the slowest release and the best character as a drug reservoir because of its slow degradation rate and semi-glass state in a biological environment. However, the corrosion rate of the PDLLA-coated Mg alloy (AZ31)-based platform was as rapid as the non-coated platform, while critical defects, cracking and desorption were observed in the PDLLA layer. Coatings comprising PCL and PLCL exhibited a prolonged platform corrosion resistance compared with that of PDLLA. To combine the advantages of each polymer, therefore, a pre-coating of PCL or PLCL was applied to the interface between the platform and the external SRL-loaded PDLLA layer. This layering exhibited an enhanced platform corrosion resistance, and will be an important foundational procedure for the development of a coronary scaffold comprising magnesium alloys.

KEYWORDS:

Biodegradable polymer; Bioresorbable scaffold; Controlled drug release; Corrosion resistance; Drug-eluting coronary stent; Magnesium alloy

PMID:
29284158
DOI:
10.1016/j.colsurfb.2017.12.032
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center