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Drug Discov Today. 2018 Oct;23(10):1746-1760. doi: 10.1016/j.drudis.2018.06.002. Epub 2018 Jun 8.

The fruit fly Drosophila melanogaster as an innovative preclinical ADME model for solute carrier membrane transporters, with consequences for pharmacology and drug therapy.

Author information

1
Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; Animal Genetics, University of Tübingen, Germany.
2
Animal Genetics, University of Tübingen, Germany; Université Côte d'Azur, CNRS, INSERM, iBV, Nice, France; Applied Zoology, TU Dresden, Germany.
3
Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; University of Tübingen, Tübingen, Germany.
4
Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; University of Tübingen, Tübingen, Germany; Department of Clinical Pharmacology, University Hospital Tübingen, Tübingen, Germany; Department of Pharmacy and Biochemistry, University of Tübingen, Tübingen, Germany. Electronic address: matthias.schwab@ikp-stuttgart.de.

Abstract

Solute carrier membrane transporters (SLCs) control cell exposure to small-molecule drugs, thereby contributing to drug efficacy and failure and/or adverse effects. Moreover, SLCs are genetically linked to various diseases. Hence, in-depth knowledge of SLC function is fundamental for a better understanding of disease pathophysiology and the drug development process. Given that the model organism Drosophila melanogaster (fruit fly) expresses SLCs, such as for the excretion of endogenous and toxic compounds by the hindgut and Malpighian tubules, equivalent to human intestine and kidney, this system appears to be a promising preclinical model to use to study human SLCs. Here, we systematically compare current knowledge of SLCs in Drosophila and humans and describe the Drosophila model as an innovative tool for drug development.

PMID:
29890226
DOI:
10.1016/j.drudis.2018.06.002
[Indexed for MEDLINE]

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