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Alcohol. 2015 Dec;49(8):773-9. doi: 10.1016/j.alcohol.2015.09.001. Epub 2015 Oct 23.

Alcohol-induced alterations in dopamine modulation of prefrontal activity.

Author information

1
Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address: tranthah@musc.edu.
2
Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.

Abstract

Long-term alcohol use leads to persistent cognitive deficits that may be associated with maladaptive changes in the neurocircuitry that mediates executive functions. Impairments caused by these changes can persist well into abstinence and have a negative impact on quality of life and job performance, and can increase the probability of relapse. Many of the changes that affect cognitive function appear to involve dysregulation of the mesocortical dopamine system. This includes changes in dopamine release and alterations in dopamine receptor expression and function in the medial prefrontal cortex (PFC). This review summarizes the cellular effects of acute and chronic ethanol exposure on dopamine release and dopamine receptor function in the PFC with the goal of providing greater understanding of the effects of alcohol-use disorders on the dopamine system and how this relates to deficits in the executive function of the PFC.

KEYWORDS:

Alcohol; Cognition; Dopamine; Prefrontal cortex

PMID:
26558348
PMCID:
PMC4691370
DOI:
10.1016/j.alcohol.2015.09.001
[Indexed for MEDLINE]
Free PMC Article

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