Format

Send to

Choose Destination
  • Filters activated: Field: Title Word. Clear all
Int J Pharm. 2017 Apr 30;522(1-2):172-197. doi: 10.1016/j.ijpharm.2017.01.067. Epub 2017 Feb 7.

Protein-based nanoparticles: From preparation to encapsulation of active molecules.

Author information

1
Univ. Lyon, University Claude Bernard Lyon-1, CNRS, LAGEP UMR 5007, 43 boulevard du 11 November 1918, F-69100, Villeurbanne, France; Faculty of Sciences, Lebanese University, B.P. 90656, Jdaidet El-Matn, Lebanon.
2
Faculty of Sciences, Lebanese University, B.P. 90656, Jdaidet El-Matn, Lebanon. Electronic address: hgreige@ul.edu.lb.
3
Univ. Lyon, University Claude Bernard Lyon-1, CNRS, LAGEP UMR 5007, 43 boulevard du 11 November 1918, F-69100, Villeurbanne, France. Electronic address: elaissari@lagep.univ-lyon1.fr.

Abstract

Nowadays, nanotechnology has become very integrated in the domain of pharmaceutical sciences since nanoparticle dispersions show various advantages as drug carriers. Among nanoparticles, the protein-based ones are of paramount importance. In fact, protein nanoparticles show many advantages over other types of nanoparticles, they are often non-toxic and biodegradable. In this review, the most common preparation methods of protein nanoparticles were targeted. In addition, the factors affecting their dispersions and the concepts of drug loading and drug release are also highlighted. It was obvious that each method can be optimized for a given protein. This issue was discussed in depth in the light of the current state of art, and supported by evidences for each method from the literature. In addition, it was concluded that the processing parameters strongly affect the properties of nanoparticles dispersion.

KEYWORDS:

Active molecules; Encapsulation; Nanoparticles; Protein

PMID:
28188876
DOI:
10.1016/j.ijpharm.2017.01.067
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center