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Biomed Mater Eng. 2018;29(2):205-215. doi: 10.3233/BME-171723.

Biodistribution of colloidal gold nanoparticles after intravenous injection: Effects of PEGylation at the same particle size.

Author information

1
Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641, Yamazaki, Noda, Chiba 278-8510, Japan.
2
Center for Drug Delivery Research, Tokyo University of Science, 2641, Yamazaki, Noda, Chiba 278-8510, Japan.
3
Center for Physical Pharmaceutics, Tokyo University of Science, 2641, Yamazaki, Noda, Chiba 278-8510, Japan.

Abstract

BACKGROUND:

Recently, polyethylene glycol (PEG) modified gold nanoparticles have been studied to maintaining long-term stability in biological fluids. Its biodistribution was also reported, however, comparison of bare gold nanoparticles and PEGylated gold nanoparticles with equal particle size is not sufficient.

OBJECTIVE:

We prepared bare gold nanoparticles and PEGylated gold nanoparticles with diameters of 20-30-nm or 50-nm to avoid the influence of particle diameter, and studied their biodistribution in the mouse.

METHODS:

Gold concentrations in brain, heart, lungs, liver, stomach, pancreas, spleen, kidneys, blood, urine, and feces were measured at 0.5, 1, 2, 3, 6, 12, 18, 24, and 48 h after administration of gold nanoparticles using inductively coupled plasma atomic emission spectrometry.

RESULTS:

At 48 h after intravenous administration, accumulation in the liver and spleen was significantly reduced by PEGylation, and the gold amounts of PEGylated gold nanoparticles with diameters of 20-30 nm and 50-nm in the brain were 3.6 times and 2.7 times higher than those of bare gold nanoparticles, respectively.

CONCLUSIONS:

These results indicated that the usefulness of PEGylated gold nanoparticles with small particle size for a drug carrier.

KEYWORDS:

Gold nanoparticles; PEGylation; biodistribution; intravenous; mPEG-thiol; mice

PMID:
29457594
DOI:
10.3233/BME-171723
[Indexed for MEDLINE]

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