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Nat Rev Genet. 2000 Nov;1(2):91-9.

Gene therapy: trials and tribulations.

Author information

1
Laboratory of Genetics, Salk Institute, 10,010 North Torrey Pines Road, La Jolla, California 92037, USA.

Abstract

The art and science of gene therapy has received much attention of late. The tragic death of 18-year-old Jesse Gelsinger, a volunteer in a Phase I clinical trial, has overshadowed the successful treatment of three children suffering from a rare but fatal immunological disease. In the light of the success and tragedy, it is timely to consider the challenges faced by gene therapy--a novel form of molecular medicine that may be poised to have an important impact on human health in the new millennium.

PMID:
11253666
DOI:
10.1038/35038533
[Indexed for MEDLINE]

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