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Indian J Pharm Sci. 2009 May;71(3):313-7. doi: 10.4103/0250-474X.56033.

Characterization of gelatin-sodium alginate complex coacervation system.

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1
Bombay College of Pharmacy, Kalina, Santacruz (East), Mumbai-400 098, India.

Abstract

A gelatin and sodium alginate complex coacervation system was studied and an effect of pH and colloid mixing ratios on coacervation was investigated. A colloid mixing ratio at which optimum coacervation occurred varied with the coacervation pH. Viscometric, turbidity and coacervate dry yield investigations were used to investigate optimum conditions for complex coacervation. Optimum coacervation occurred at pH 3.5 at a gelatin sodium alginate ratio 4:1. Coacervate and equilibrium fluid was analyzed for gelatin and sodium alginate contents and yields calculated on the basis of chemical analysis showed that optimum coacervation occurred at 25% sodium alginate fraction at pH 3.5.

KEYWORDS:

Complex coacervation; gelatin; phase separation; sodium alginate

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