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ACS Nano. 2016 Mar 22;10(3):3323-33. doi: 10.1021/acsnano.5b06939. Epub 2016 Mar 7.

Blood Exosomes Endowed with Magnetic and Targeting Properties for Cancer Therapy.

Author information

1
Tianjin Key Laboratory of Composite and Functional Materials, School of Material Science and Engineering, Tianjin University , Tianjin 300072, China.
2
Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Department of Neurosurgery, Tianjin Medical University General Hospital and Key Laboratory of Neurotrauma, Variation, and Regeneration, Ministry of Education and Tianjin Municipal Government , Tianjin 300052, China.
3
Tianjin Research Center of Basic Medical Science, Tianjin Medical University , Tianjin 300070, China.
4
Department of Surgery, Second Hospital of Tianjin Medical University , Tianjin 300211, China.

Abstract

Exosomes are a class of naturally occurring nanoparticles that are secreted endogenously by mammalian cells. Clinical applications for exosomes remain a challenge because of their unsuitable donors, low scalability, and insufficient targeting ability. In this study, we developed a dual-functional exosome-based superparamagnetic nanoparticle cluster as a targeted drug delivery vehicle for cancer therapy. The resulting exosome-based drug delivery vehicle exhibits superparamagnetic behavior at room temperature, with a stronger response to an external magnetic field than individual superparamagnetic nanoparticles. These properties enable exosomes to be separated from the blood and to target diseased cells. In vivo studies using murine hepatoma 22 subcutaneous cancer cells showed that drug-loaded exosome-based vehicle delivery enhanced cancer targeting under an external magnetic field and suppressed tumor growth. Our developments overcome major barriers to the utility of exosomes for cancer application.

KEYWORDS:

cancer targeting; drug delivery; exosome; scalable separation; superparamagnetic nanoparticle clusters

PMID:
26938862
DOI:
10.1021/acsnano.5b06939
[Indexed for MEDLINE]

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