Format

Send to

Choose Destination
  • Filters activated: Field: Title Word. Clear all
Psychiatr Clin North Am. 2016 Jun;39(2):165-74. doi: 10.1016/j.psc.2016.01.001. Epub 2016 Feb 28.

Does Biology Transcend the Symptom-based Boundaries of Psychosis?

Author information

1
Olin Neuropsychiatry Research Center, Institute of Living, 200 Retreat Avenue, Hartford, CT 06106, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: godfrey.pearlson@yale.edu.
2
Department of Psychology, University of Georgia, Athens, GA 30602, USA.
3
Department of Psychiatry, UT Southwestern Medical School, Dallas, TX 75390, USA.
4
Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

Abstract

Psychotic disorders, as defined by clinical features alone, overlap considerably in terms of symptoms, familial patterns, risk genes, outcome, and treatment response. As a result, numerous neurobiological measurements fail to distinguish patients with the most prevalent classic psychotic syndromes. Statistical methods applied to such biological measurements in large numbers of patients with psychosis yield novel categories that cut across traditional diagnostic boundaries. Such new classification approaches within psychosis hopefully represent an opportunity to transcend clinical phenomenologically defined syndromes in psychiatry with neurobiologically defined diseases that can advance drug discovery and support precision medicine approaches in psychiatry.

KEYWORDS:

Biotype; Bipolar; Neurobiology; Psychosis; Reclassification; Schizoaffective; Schizophrenia

PMID:
27216897
PMCID:
PMC4955658
DOI:
10.1016/j.psc.2016.01.001
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center