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Eur J Pharm Sci. 2018 Jul 30;120:199-211. doi: 10.1016/j.ejps.2018.05.004. Epub 2018 May 8.

How to measure release from nanosized carriers?

Author information

1
Department of Pharmaceutical Technology and Nanosciences, Fraunhofer-Institute for Molecular Biology and Applied Ecology (IME), 60438 Frankfurt am Main, Germany.
2
Department of Pharmaceutical Technology and Nanosciences, Fraunhofer-Institute for Molecular Biology and Applied Ecology (IME), 60438 Frankfurt am Main, Germany; Institute of Pharmaceutical Technology, Goethe University, 60438 Frankfurt am Main, Germany. Electronic address: matthias.wacker@ime.fraunhofer.de.

Abstract

Novel drug delivery systems exhibit great potential in the formulation of poorly soluble compounds but have also been applied to reduce side effects of highly active drug molecules. Despite all efforts, there are only few technologies available to investigate the in vitro release of next-generation nanotherapeutics. In the following, different approaches for testing the drug release from nanoparticles in the fields of formulation development and quality control will be discussed. A variety of methods is available, starting from dialysis-based equipment, in situ measurements, flow-through devices and sample and separate setups. If possible, these methods should enable a more rapid formulation development and quality control of nanosized carriers as well as improve the prediction of in vivo performance and clinical outcomes.

KEYWORDS:

Dialysis; Dissolution; Drug delivery; Drug release; IVIVC; Nanoparticles; Sample and separate

PMID:
29751101
DOI:
10.1016/j.ejps.2018.05.004
[Indexed for MEDLINE]

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