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Neurol Res. 2018 Dec;40(12):1060-1070. doi: 10.1080/01616412.2018.1517859. Epub 2018 Sep 22.

Evaluation of dexamethasone treated mesenchymal stem cells for recovery in neurotmesis model of peripheral nerve injury.

Author information

1
a Department of Animal Biology, Faculty of Biological Science , Kharazmi University , Tehran , Iran.
2
b Faculty of Agriculture and Natural Resources , Persian Gulf University , Bushehr , Iran.
3
c Neuroscience Research Center , Baqiyatallah University of Medical Sciences , Tehran , Iran.
4
d Department of Anatomy , Fasa University of Medical Science , Fasa , Fars , Iran.
5
e Department of Physical Medicine, and Rehabilitation , Iran University of Medical Sciences , Tehran , Iran.

Abstract

OBJECTIVE:

Peripheral nerve injuries comprise significant portion of the nervous system injuries. Although peripheral nerves show some capacity of regeneration after injury, the extent of regeneration is not remarkable. The present study aimes to evaluate the regeneration of transected sciatic nerve by a therapeutic value of dexamethasone (DEX) associated with cell therapy (Cell) and biodegradable membrane (Mem) in rat.

METHODS:

Male Wistar rats (n = 42, 180-200g) were randomly divided into control (Ctrl), Membrane+ Cell, Mem, DEX, DEX+ Cell, DEX+ Mem and DEX+ Cell+ Mem groups. Functional recovery was evaluated at 2, 4, 6, 8 and 12 weeks after surgery using sciatic functional index (SFI), withdrawal reflex latency (WRL) test, electrophysiological and histological analyses.

RESULTS:

The rats in the DEX+ Cell+ Mem-treated group showed a significant improvement in SFI, WRL and electrophysiological findings during the 2nd to 12th weeks after surgery. In addition, histomorphological findings showed a significant improvement in the DEX+ Cell+ Memtreated group, at 12 weeks after surgery.

DISCUSSION:

Taken together, use of DEX associated with cell and biodegradable membrane could improve functional and histomorphological properties of the sciatic nerve after injury.

KEYWORDS:

Cell; dexamethasone; membrane; repair; sciatic nerve

PMID:
30246623
DOI:
10.1080/01616412.2018.1517859
[Indexed for MEDLINE]

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