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Oxid Med Cell Longev. 2013;2013:575482. doi: 10.1155/2013/575482. Epub 2013 Apr 4.

A review of pterostilbene antioxidant activity and disease modification.

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1
Mailman School of Public Health, Columbia University, Allan Rosenfield Building, 722 West 168th Street, New York, NY 10032, USA.

Abstract

Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) is a natural dietary compound and the primary antioxidant component of blueberries. It has increased bioavailability in comparison to other stilbene compounds, which may enhance its dietary benefit and possibly contribute to a valuable clinical effect. Multiple studies have demonstrated the antioxidant activity of pterostilbene in both in vitro and in vivo models illustrating both preventative and therapeutic benefits. The antioxidant activity of pterostilbene has been implicated in anticarcinogenesis, modulation of neurological disease, anti-inflammation, attenuation of vascular disease, and amelioration of diabetes. In this review, we explore the antioxidant properties of pterostilbene and its relationship to common disease pathways and give a summary of the clinical potential of pterostilbene in the prevention and treatment of various medical conditions.

PMID:
23691264
PMCID:
PMC3649683
DOI:
10.1155/2013/575482
[Indexed for MEDLINE]
Free PMC Article

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