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1.
Nanomedicine (Lond). 2017 Jun;12(11):1335-1352. doi: 10.2217/nnm-2017-0017. Epub 2017 May 18.

Recent advances in electrospun nanofibers for wound healing.

Author information

1
Department of Surgery-Transplant & Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE 68198, USA.
2
Department of Anorectal Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China.
3
Departments of Surgery & Genetics, Cell Biology & Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, USA.
4
Department of Surgery, VA Nebraska-Western Iowa Health Care System, Omaha, NE 68105, USA.
5
Department of Biochemistry & Biophysics & Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.
6
Departments of Surgery-Plastic & Reconstructive Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Abstract

Electrospun nanofibers represent a novel class of materials that show great potential in many biomedical applications including biosensing, regenerative medicine, tissue engineering, drug delivery and wound healing. In this work, we review recent advances in electrospun nanofibers for wound healing. This article begins with a brief introduction on the wound, and then discusses the unique features of electrospun nanofibers critical for wound healing. It further highlights recent studies that have used electrospun nanofibers for wound healing applications and devices, including sutures, multifunctional dressings, dermal substitutes, engineered epidermis and full-thickness skin regeneration. Finally, we finish with conclusions and future perspective in this field.

KEYWORDS:

electrospun nanofibers; local drug delivery; scaffold; skin regeneration; wound healing

PMID:
28520509
DOI:
10.2217/nnm-2017-0017
[Indexed for MEDLINE]
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2.
Mater Sci Eng C Mater Biol Appl. 2017 Jul 1;76:1413-1423. doi: 10.1016/j.msec.2017.03.034. Epub 2017 Mar 14.

Electrospun nanofibers for wound healing.

Author information

1
College of Chemical Engineering & Materials Science, Quanzhou Normal University, Quanzhou, China.
2
College of Chemical Engineering & Materials Science, Quanzhou Normal University, Quanzhou, China; Collaborative Innovation Center for Nanomaterials & Optoelectronic Devices, College of Physics, Qingdao University, Qingdao 266071, China.
3
Collaborative Innovation Center for Nanomaterials & Optoelectronic Devices, College of Physics, Qingdao University, Qingdao 266071, China.
4
College of Chemical Engineering & Materials Science, Quanzhou Normal University, Quanzhou, China. Electronic address: yangdp@qztc.edu.cn.
5
College of Chemical Engineering & Materials Science, Quanzhou Normal University, Quanzhou, China; Collaborative Innovation Center for Nanomaterials & Optoelectronic Devices, College of Physics, Qingdao University, Qingdao 266071, China. Electronic address: yunze.long@163.com.

Abstract

Electrospinning has been widely used as a nanofiber fabrication technique. Its simple process, cost effectiveness and versatility have appealed to materials scientists globally. Pristine polymeric nanofibers or composite nanofibers with dissimilar morphologies and multidimensional assemblies ranging from one dimension (1D) to three dimensions (3D) can be obtained from electrospinning. Critically, these as-prepared nanofibers possessing high surface area to volume ratio, tunable porosity and facile surface functionalization present numerous possibilities for applications, particularly in biomedical field. This review gives us an overview of some recent advances of electrospinning-based nanomaterials in biomedical applications such as antibacterial mats, patches for rapid hemostasis, wound dressings, drug delivery systems, as well as tissue engineering. We further highlight the current challenges and future perspectives of electrospinning-based nanomaterials in the field of biomedicine.

PMID:
28482508
DOI:
10.1016/j.msec.2017.03.034
[Indexed for MEDLINE]
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3.
Colloids Surf B Biointerfaces. 2016 Jul 1;143:415-422. doi: 10.1016/j.colsurfb.2016.03.052. Epub 2016 Mar 18.

Electrospun tilapia collagen nanofibers accelerating wound healing via inducing keratinocytes proliferation and differentiation.

Author information

1
Shanghai Biomaterials Research & Testing Center, Shanghai Key Laboratory of Stomatology, Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200023, China.
2
Shanghai Fisheries Research Institute, Shanghai 200433, China.
3
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China. Electronic address: xmm@dhu.edu.cn.
4
Shanghai Biomaterials Research & Testing Center, Shanghai Key Laboratory of Stomatology, Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200023, China. Electronic address: jiaosun59@126.com.

Abstract

The development of biomaterials with the ability to induce skin wound healing is a great challenge in biomedicine. In this study, tilapia skin collagen sponge and electrospun nanofibers were developed for wound dressing. The collagen sponge was composed of at least two α-peptides. It did not change the number of spleen-derived lymphocytes in BALB/c mice, the ratio of CD4(+)/CD8(+) lymphocytes, and the level of IgG or IgM in Sprague-Dawley rats. The tensile strength and contact angle of collagen nanofibers were 6.72±0.44MPa and 26.71±4.88°, respectively. They also had good thermal stability and swelling property. Furthermore, the nanofibers could significantly promote the proliferation of human keratinocytes (HaCaTs) and stimulate epidermal differentiation through the up-regulated gene expression of involucrin, filaggrin, and type I transglutaminase in HaCaTs. The collagen nanofibers could also facilitate rat skin regeneration. In the present study, electrospun biomimetic tilapia skin collagen nanofibers were succesfully prepared, were proved to have good bioactivity and could accelerate rat wound healing rapidly and effectively. These biological effects might be attributed to the biomimic extracellular matrix structure and the multiple amino acids of the collagen nanofibers. Therefore, the cost-efficient tilapia collagen nanofibers could be used as novel wound dressing, meanwhile effectively avoiding the risk of transmitting animal disease in the future clinical apllication.

KEYWORDS:

Electrospun tilapia collagen nanofibers; HaCaTs differentiation; Rat model; Skin wound healing

PMID:
27037778
DOI:
10.1016/j.colsurfb.2016.03.052
[Indexed for MEDLINE]
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