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Mater Sci Eng C Mater Biol Appl. 2018 Sep 1;90:159-167. doi: 10.1016/j.msec.2018.04.045. Epub 2018 Apr 17.

Bone marrow-derived mesenchymal stem cells laden novel thermo-sensitive hydrogel for the management of severe skin wound healing.

Author information

1
Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
2
Department of Mechanical Engineering, Biochemistry and Medical Genetics, University of Manitoba, Manitoba Institute of Child Health, Winnipeg, MB R3T 2N2, Canada.
3
Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China; Elderly Health Services Research Center, Southern Medical University, Guangzhou 510515, China. Electronic address: zlulu70@126.com.
4
Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China. Electronic address: zlilyzh@126.com.

Abstract

Bone marrow-derived mesenchymal stem cells (BMSCs) are easy to collect and culture, and it is identified that it has multi-directional differentiation potential, moreover it has low immunogenicity, hence it can be used as an allogeneic cell source for skin wound healing. Hydrogel has been widely used in skin wound healing own to it is able to mimic the 3D microenvironment of cells, which supports cell proliferation, migration and secretion. In this study, we created a novel biocompatible thermo-sensitive hydrogel to carry BMSCs for full-thickness skin wound healing. The thermo-sensitive hydrogel loaded with BMSCs can fast achieve sol-gel transition after implanting to the wound. Histological results confirmed that hydrogel-BMSCs combination group showed significant promotion of wound closure, epithelial cells' proliferation and re-epithelialization, and reduced inflammatory responses in the wounds and in the tissues surrounding the wounds. The combination therapy also can promote collagen deposition, TGF-β1 and bFGF secretion and tissue remodeling. The present study provides a promising strategy for the clinical treatment of skin wounds.

KEYWORDS:

Bone marrow-derived mesenchymal stem cells (BMSCs); Fibroblast growth factor (FGF); Hydrogel; Skin wound healing; Transforming growth factor beta 1 (TGF-β1)

PMID:
29853078
DOI:
10.1016/j.msec.2018.04.045
[Indexed for MEDLINE]

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