Format

Send to

Choose Destination
  • Filters activated: Field: Title Word. Clear all
Drug Discov Today Technol. 2017 Mar;23:75-82. doi: 10.1016/j.ddtec.2017.03.003. Epub 2017 Apr 14.

Natural product inspired compound collections: evolutionary principle, chemical synthesis, phenotypic screening, and target identification.

Author information

1
Max Planck Institute of Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Str. 11, 44227 Dortmund, Germany.
2
Max Planck Institute of Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Str. 11, 44227 Dortmund, Germany; Technische Universität Dortmund, Fakultät Chemie und Chemische Biologie, Otto-Hahn-Str. 6, 44227 Dortmund, Germany. Electronic address: herbert.waldmann@mpi-dortmund.mpg.de.

Abstract

Natural products have been an excellent and abundant source of therapeutics for many decades. To expand on their success, and explore areas of chemical space not covered by biosynthesis, the synthesis of natural product-inspired compound collections has emerged as a viable strategy. Herein we describe the principles behind biology-oriented synthesis and related approaches, the requirements for development of novel chemistry and how phenotypic screens are a very fruitful way to explore the bioactivity of compounds made using these approaches. Finally, we summarize state-of-the-art techniques to identify the biological targets of any hits identified.

PMID:
28647090
DOI:
10.1016/j.ddtec.2017.03.003
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center