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1.
Eur J Vasc Endovasc Surg. 2015 May;49(5):613-4. doi: 10.1016/j.ejvs.2015.02.010. Epub 2015 Mar 14.

Re: 'response to letter to the editor on "Galectin-3, carotid plaque vulnerability, and potential effects of statin therapy"'.

Author information

1
Department of Vascular Surgery, Medical School, University of Athens, Athens, Greece. Electronic address: nikoskad@yahoo.com.
2
Department of Vascular Surgery, Medical School, University of Athens, Athens, Greece.
3
Department of Cytopathology, "Attikon" University Hospital, Athens, Greece.
4
School of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece.
PMID:
25784505
DOI:
10.1016/j.ejvs.2015.02.010
[Indexed for MEDLINE]
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2.
Eur J Vasc Endovasc Surg. 2015 Jan;49(1):4-9.

Galectin-3, Carotid Plaque Vulnerability, and Potential Effects of Statin Therapy.

Abstract

OBJECTIVES:

Galectin-3, a member of galectines, a family of b-galactoside-specific lectins, has been reported to propagate vascular inflammation. The role of galectin-3 in carotid atherosclerosis is controversial. The aim of this study was to investigate the relationship of galectin-3 with plaque vulnerability in patients with high grade carotid stenosis.

METHODS:

This was a cross sectional study of patients undergoing carotid endarterectomy (CEA). Carotid plaques obtained from 78 consecutive patients (40 symptomatic [SG], 38 asymptomatic [AG]) undergoing CEA were histologically analyzed for galectin-3, macrophages (CD68) and laminin. Pre-operatively the biochemical profile and plaque echogenicity (gray-scale median, GSM) score were determined.

RESULTS:

There were no significant differences in clinical and demographic parameters between SG and AG(p > .05). The SG had a lower GSM score (44.21 ± 18.24 vs. 68.79 ± 28.79, p < .001) and a smaller positive stained area for galectin-3 (4.89 ± 1.60% vs. 12.01 ± 5.91%, p < .001) and laminin (0.88 ± 0.71% vs. 3.46 ± 2.12%, p < .001) than the AG. On the other hand, intra-plaque macrophage content was increased in SG (p < .001). For the whole cohort, symptomatic status was independently associated with intra-plaque contents of both galectin-3 (OR=0.634, p < .001), and GSM score (OR=0.750, p < .001). Notably, patients on long term statin treatment had elevated galectin-3 and lowered macrophage intra-plaque concentrations compared with those on short term treatment (p < .05).

CONCLUSIONS:

A low galectin-3 intra-plaque concentration seems to correlate with clinically and ultrasonically defined unstable human carotid plaques. Long term statin treatment may induce increase of intra-plaque galectin-3 concentration mediating plaque stabilization.

PMID:
25457298
DOI:
10.1016/j.ejvs.2014.10.009
[Indexed for MEDLINE]
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