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J Control Release. 2014 Jul 10;185:12-21. doi: 10.1016/j.jconrel.2014.04.018. Epub 2014 Apr 22.

Electrospinning of polymeric nanofibers for drug delivery applications.

Author information

1
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
2
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China; The University of Chinese Academy of Sciences, Beijing 100049, PR China.
3
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
4
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China. Electronic address: ybhuang@ciac.ac.cn.
5
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China. Electronic address: xiez@ciac.ac.cn.

Abstract

Electrospinning has been recognized as a simple and versatile method for fabrication of polymer nanofibers. Various polymers that include synthetic, natural, and hybrid materials have been successfully electrospun into ultrafine fibers. The inherently high surface to volume ratio of electrospun fibers can enhance cell attachment, drug loading, and mass transfer properties. Drugs ranging from antibiotics and anticancer agents to proteins, DNA, RNA, living cells, and various growth factors have been incorporated into electrospun fibers. This article presents an overview of electrospinning techniques and their application in drug delivery.

KEYWORDS:

Drug delivery; Electrospinning; Local chemotherapy; Wound dressing

PMID:
24768792
DOI:
10.1016/j.jconrel.2014.04.018
[Indexed for MEDLINE]

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