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Nanomedicine (Lond). 2016 Mar;11(6):673-92. doi: 10.2217/nnm.16.5. Epub 2016 Mar 22.

The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction.

Author information

1
Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA 30332, USA.
2
Department of Radiology, Peking University Third Hospital, Beijing 100191, China.
3
Department of Bioengineering, Rice University, Houston, TX 77030, USA.

Abstract

Nanoparticle-based technologies offer exciting new approaches to disease diagnostics and therapeutics. To take advantage of unique properties of nanoscale materials and structures, the size, shape and/or surface chemistry of nanoparticles need to be optimized, allowing their functionalities to be tailored for different biomedical applications. Here we review the effects of nanoparticle size on cellular interaction and in vivo pharmacokinetics, including cellular uptake, biodistribution and circulation half-life of nanoparticles. Important features of nanoparticle probes for molecular imaging and modeling of nanoparticle size effects are also discussed.

KEYWORDS:

cellular uptake; in vivo pharmacokinetics; modeling; nanoparticle; size effect

PMID:
27003448
PMCID:
PMC5561790
DOI:
10.2217/nnm.16.5
[Indexed for MEDLINE]
Free PMC Article

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