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Nat Prod Rep. 2008 Oct;25(5):892-904. doi: 10.1039/b715668p. Epub 2008 Jul 7.

Scaffold diversity of natural products: inspiration for combinatorial library design.

Author information

1
Institute of Organic Chemistry and Chemical Biology, ZAFES/CMP, Goethe-University, Siesmayerstrasse 70, Frankfurt a.M., Germany.

Abstract

Natural products contain scaffold structures that can be systematically exploited for the design of combinatorial compound libraries with druglike properties. We review approaches for scaffold identification, and compare properties and pharmacophoric features of drugs and natural products. In particular, an application of the self-organizing map technique is presented for natural product-derived compound and library design.

PMID:
18820757
DOI:
10.1039/b715668p
[Indexed for MEDLINE]

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