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Nanoscale. 2017 Jan 7;9(1):99-103. doi: 10.1039/c6nr08282c. Epub 2016 Dec 9.

Large photoacoustic effect enhancement for ICG confined inside MCM-41 mesoporous silica nanoparticles.

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Department of Molecular Biotechnology and Health Sciences, University of Turin, Via Nizza 52, 10126 Turin, Italy.


Indocyanine green was encapsulated inside the pores of pegylated amino-functionalized MCM-41 Mesoporous Silica Nanoparticles (ICG-MSNs). In addition to a greater stability and a decrease of toxicity, the photoacoustic effect of ICG-MSNs increases by nearly 400% compared to free ICG due to fluorescence quenching and high photothermal conversion of the encapsulated dyes. Upon i.v. administration in tumor-bearing mice, an overall photoacoustic enhancement of ca. 25% was measured in the tumor region.


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