Format

Send to

Choose Destination
  • Filters activated: Field: Title Word. Clear all
Int J Nanomedicine. 2017 Aug 21;12:6027-6044. doi: 10.2147/IJN.S132434. eCollection 2017.

Liposomal curcumin and its application in cancer.

Author information

1
Department of Pharmaceutics, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, People's Republic of China.
2
Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
#
Contributed equally

Abstract

Curcumin (CUR) is a yellow polyphenolic compound derived from the plant turmeric. It is widely used to treat many types of diseases, including cancers such as those of lung, cervices, prostate, breast, bone and liver. However, its effectiveness has been limited due to poor aqueous solubility, low bioavailability and rapid metabolism and systemic elimination. To solve these problems, researchers have tried to explore novel drug delivery systems such as liposomes, solid dispersion, microemulsion, micelles, nanogels and dendrimers. Among these, liposomes have been the most extensively studied. Liposomal CUR formulation has greater growth inhibitory and pro-apoptotic effects on cancer cells. This review mainly focuses on the preparation of liposomes containing CUR and its use in cancer therapy.

KEYWORDS:

bioavailability; cancer; curcumin; drug delivery; liposomes

PMID:
28860764
PMCID:
PMC5573051
DOI:
10.2147/IJN.S132434
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Dove Medical Press Icon for PubMed Central
Loading ...
Support Center