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J Drug Target. 2019 Aug 13:1-20. doi: 10.1080/1061186X.2019.1648479. [Epub ahead of print]

Liposome-ligand conjugates: a review on the current state of art.

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a Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Hacettepe University , Ankara , Turkey.


Early researchers focussed on developing stimuli-responsive liposomes in order to manipulate drug release at the site of action or under certain conditions. In recent times, a great deal of efforts has been made to modify the surface of liposomes with ligands for the purpose of achieving targeted drug delivery. Due to the morphology of liposomes, their surfaces can be engineered by attaching molecules such as oligosaccharides, peptides, antibodies, antigens and oligonucleotides to the bilayer structure. Over the years, a number of techniques including the use of covalent and non-covalent linkages have been utilised in designing ligand-liposome conjugates. In this review, various strategies for the functionalisation of liposomes as well as the different types of ligand-liposome conjugates have been discussed. Finally, the pros and cons of conjugation in liposomes are concisely summarised.


Liposome; conjugation; drug delivery; ligand

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