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Genes (Basel). 2018 Jul 23;9(7). pii: E370. doi: 10.3390/genes9070370.

Bioengineering Strategies for Protein-Based Nanoparticles.

Diaz D1, Care A2,3, Sunna A4,5,6.

Author information

1
Department of Molecular Sciences, Macquarie University, Sydney, NSW 2109, Australia. dennis.diaz-rincon@hdr.mq.edu.au.
2
Department of Molecular Sciences, Macquarie University, Sydney, NSW 2109, Australia. andrew.care@mq.edu.au.
3
Australian Research Council Centre of Excellence for Nanoscale BioPhotonics, Macquarie University, Sydney, NSW 2109, Australia. andrew.care@mq.edu.au.
4
Department of Molecular Sciences, Macquarie University, Sydney, NSW 2109, Australia. anwar.sunna@mq.edu.au.
5
Australian Research Council Centre of Excellence for Nanoscale BioPhotonics, Macquarie University, Sydney, NSW 2109, Australia. anwar.sunna@mq.edu.au.
6
Biomolecular Discovery and Design Research Centre, Macquarie University, Sydney, NSW 2109, Australia. anwar.sunna@mq.edu.au.

Abstract

In recent years, the practical application of protein-based nanoparticles (PNPs) has expanded rapidly into areas like drug delivery, vaccine development, and biocatalysis. PNPs possess unique features that make them attractive as potential platforms for a variety of nanobiotechnological applications. They self-assemble from multiple protein subunits into hollow monodisperse structures; they are highly stable, biocompatible, and biodegradable; and their external components and encapsulation properties can be readily manipulated by chemical or genetic strategies. Moreover, their complex and perfect symmetry have motivated researchers to mimic their properties in order to create de novo protein assemblies. This review focuses on recent advances in the bioengineering and bioconjugation of PNPs and the implementation of synthetic biology concepts to exploit and enhance PNP's intrinsic properties and to impart them with novel functionalities.

KEYWORDS:

biocatalysis; bioengineering; biomedicine; nanobiotechnology; nanocages; protein-based nanoparticles; synthetic biology; virus-like particle

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