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Int J Pharm. 2015 Jul 15;489(1-2):1-10. doi: 10.1016/j.ijpharm.2015.04.056. Epub 2015 Apr 18.

Ultradeformable liposomes as multidrug carrier of resveratrol and 5-fluorouracil for their topical delivery.

Author information

1
Department of Health Sciences, University "Magna Græcia" of Catanzaro, Campus Universitario "S. Venuta", Viale S. Venuta, Germaneto, I-88100 Catanzaro, Italy; IRC FSH - Interregional Research Center for Food Safety & Health, University of Catanzaro "Magna Græcia", Campus Universitario "S. Venuta" - Building of BioSciences, Viale S. Venuta, I-88100 Germaneto, Catanzaro, Italy.
2
Department of Health Sciences, University "Magna Græcia" of Catanzaro, Campus Universitario "S. Venuta", Viale S. Venuta, Germaneto, I-88100 Catanzaro, Italy.
3
Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, Via dei Vestini 31, I-66100 Chieti, Italy.
4
Department of Drug Chemistry and Technologies, University "Sapienza" of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
5
Department of Drug Science and Health Products, University of Messina, Viale Annunziata, 98168 Messina, Italy.
6
Department of Health Sciences, University "Magna Græcia" of Catanzaro, Campus Universitario "S. Venuta", Viale S. Venuta, Germaneto, I-88100 Catanzaro, Italy; IRC FSH - Interregional Research Center for Food Safety & Health, University of Catanzaro "Magna Græcia", Campus Universitario "S. Venuta" - Building of BioSciences, Viale S. Venuta, I-88100 Germaneto, Catanzaro, Italy. Electronic address: fresta@unicz.it.

Abstract

Ultradeformable liposomes represent useful formulations able to increase the skin permeation of drug compounds. In this study, resveratrol- and 5-fluorouracil-loaded ultradeformable liposomes were investigated for the potential treatment of non-melanoma skin cancer. The in vitro anticancer activity of ultradeformable liposomes was tested on human skin cancer cells through viability-, cell cycle- and apoptosis-analysis. Furthermore, we tested the percutaneous permeation of ultradeformable liposomes using human stratum corneum and viable epidermis. The co-encapsulation of resveratrol and 5-fluorouracil (multi-drug carrier) in ultradeformable liposomes improved their anticancer activity on skin cancer cells as compared to both the free drug form and the single entrapped agents. These multi-drug ultradeformable liposomes arrest cell proliferation in G1/S, thus modifying the action of 5-fluorouracil and increasing the activity of resveratrol. This effect might depend on the ultradeformable liposomes, which may accumulate in deeper skin layers, thus generating a cutaneous depot from which resveratrol and 5-fluorouracil are gradually released. Resveratrol and 5-fluorouracil co-loaded ultradeformable liposomes could be a new nanomedicine for the treatment of squamous cell carcinoma, i.e., actinic keratosis, Bowen's disease, and keratoacanthoma.

KEYWORDS:

Multi-drug colloidal carriers; Skin cancer; Skin delivery; Supramolecular therapeutics; Ultradeformable liposomes

PMID:
25899287
DOI:
10.1016/j.ijpharm.2015.04.056
[Indexed for MEDLINE]

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