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Curr Opin Neurobiol. 2016 Feb;36:7-14. doi: 10.1016/j.conb.2015.07.008. Epub 2015 Aug 11.

Functional connectivity measures as schizophrenia intermediate phenotypes: advances, limitations, and future directions.

Author information

1
Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany.
2
Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany. Electronic address: heike.tost@zi-mannheim.de.

Abstract

The search for quantifiable biological mediators of genetic risk or 'intermediate phenotypes' is an essential strategy in psychiatric neuroscience and a useful tool for exploring the complex relationships between genes, neural circuits and behaviors. In recent years, the examination of connectivity-based intermediate phenotypes has gained increasing popularity in the study of schizophrenia, a brain disorder that manifests in early adulthood and disturbs a wide range of neural network functions. To date, several potential connectivity phenotypes have been identified that link neuroimaging measures of neural circuit interaction to genetic susceptibility for schizophrenia. This paper briefly reviews recent advances, current limitations and future directions in the search for functional connectivity intermediate phenotypes for schizophrenia across different cognitive domains.

PMID:
26276700
DOI:
10.1016/j.conb.2015.07.008
[Indexed for MEDLINE]

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