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ACS Nano. 2016 Aug 23;10(8):7738-48. doi: 10.1021/acsnano.6b03148. Epub 2016 Jul 27.

Liposomes Coated with Isolated Macrophage Membrane Can Target Lung Metastasis of Breast Cancer.

Cao H1,2, Dan Z1, He X1,2, Zhang Z1, Yu H1, Yin Q1, Li Y1.

Author information

1
State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, China.
2
University of Chinese Academy of Sciences , Beijing 100049, China.

Abstract

Cancer metastasis leads to high mortality of breast cancer and is difficult to treat because of the poor delivery efficiency of drugs. Herein, we report the wrapping of a drug-carrying liposome with an isolated macrophage membrane to improve delivery to metastatic sites. The macrophage membrane decoration increased cellular uptake of the emtansine liposome in metastatic 4T1 breast cancer cells and had inhibitory effects on cell viability. In vivo, the macrophage membrane enabled the liposome to target metastatic cells and produced a notable inhibitory effect on lung metastasis of breast cancer. Our results provide a biomimetic strategy via the biological properties of macrophages to enhance the medical performance of a nanoparticle in vivo for treating cancer metastasis.

KEYWORDS:

breast cancer; drug delivery; liposome; macrophage; metastasis

PMID:
27454827
DOI:
10.1021/acsnano.6b03148
[Indexed for MEDLINE]

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