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1.
J Control Release. 2016 Sep 28;238:311-312. doi: 10.1016/j.jconrel.2016.07.002. Epub 2016 Jul 8.

In relation to the following article "DLS and zeta potential - What they are and what they are not?" Journal of Controlled Release, 2016, 235, 337-351.

Author information

1
School of Veterinary Medicine, University College Dublin (UCD), Belfield, Dublin 4, Ireland. Electronic address: sourav.bhattacharjee@ucd.ie.

Abstract

This Letter to the Editor is written to provide with a corrigendum along with some short technical notes as additional supplementary materials to the recently published review article in JCR, "DLS and zeta potential - What they are and what they are not?".

KEYWORDS:

Cumulant analysis; Mie's theory; Nano-DDS; RGD approximation; Rayleigh scattering

PMID:
27397489
DOI:
10.1016/j.jconrel.2016.07.002
[Indexed for MEDLINE]
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2.
J Control Release. 2016 Aug 10;235:337-351. doi: 10.1016/j.jconrel.2016.06.017. Epub 2016 Jun 10.

DLS and zeta potential - What they are and what they are not?

Author information

1
School of Veterinary Medicine, University College Dublin (UCD), Belfield, Dublin 4, Ireland. Electronic address: sourav.bhattacharjee@ucd.ie.

Abstract

Adequate characterization of NPs (nanoparticles) is of paramount importance to develop well defined nanoformulations of therapeutic relevance. Determination of particle size and surface charge of NPs are indispensable for proper characterization of NPs. DLS (dynamic light scattering) and ZP (zeta potential) measurements have gained popularity as simple, easy and reproducible tools to ascertain particle size and surface charge. Unfortunately, on practical grounds plenty of challenges exist regarding these two techniques including inadequate understanding of the operating principles and dealing with critical issues like sample preparation and interpretation of the data. As both DLS and ZP have emerged from the realms of physical colloid chemistry - it is difficult for researchers engaged in nanomedicine research to master these two techniques. Additionally, there is little literature available in drug delivery research which offers a simple, concise account on these techniques. This review tries to address this issue while providing the fundamental principles of these techniques, summarizing the core mathematical principles and offering practical guidelines on tackling commonly encountered problems while running DLS and ZP measurements. Finally, the review tries to analyze the relevance of these two techniques from translatory perspective.

KEYWORDS:

Colloid stability; DLS; Hydrodynamic radius; Surface charge; Surface potential; Zeta potential

PMID:
27297779
DOI:
10.1016/j.jconrel.2016.06.017
[Indexed for MEDLINE]
Icon for Elsevier Science

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