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Am J Psychiatry. 1999 Jun;156(6):952-4.

Preliminary evidence of low cortical GABA levels in localized 1H-MR spectra of alcohol-dependent and hepatic encephalopathy patients.

Author information

1
Department of Neurology, Yale University, New Haven, CT 06520-8043, USA. kevin.behar@yale.edu

Abstract

OBJECTIVE:

The aim of the study was to compare levels of neuroactive amino acids in the cerebral cortex of healthy subjects, recently detoxified alcohol-dependent patients, and patients with hepatic encephalopathy.

METHOD:

Metabolite levels were measured in the occipital cortex by using spatially localized 1H-MRS. Five recently detoxified alcohol-dependent and five hepatic encephalopathy patients with alcohol and non-alcohol-related disease were compared with 10 healthy subjects.

RESULTS:

The combined level of gamma-aminobutyric acid (GABA) plus homocarnosine was lower in the alcohol-dependent and hepatic encephalopathy patients than in the healthy subjects.

CONCLUSIONS:

The findings suggest that GABA-ergic systems are altered in both alcohol-dependent and hepatic encephalopathy patients.

PMID:
10360140
DOI:
10.1176/ajp.156.6.952
[Indexed for MEDLINE]

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