Format

Send to

Choose Destination
  • Filters activated: Field: Title Word. Clear all
PLoS One. 2015 Sep 11;10(9):e0137207. doi: 10.1371/journal.pone.0137207. eCollection 2015.

Nanoparticles Containing Curcumin Useful for Suppressing Macrophages In Vivo in Mice.

Author information

1
R&D Division, Katayama Chemical Industries, Co., Ltd., Minoh-City, Osaka, Japan.
2
Department of Food and Nutrition, Faculty of Human Life Science, Senri Kinran University, Suita-City, Osaka, Japan.

Abstract

To explore a novel method using liposomes to suppress macrophages, we screened food constituents through cell culture assays. Curcumin was one of the strongest compounds exhibiting suppressive effects on macrophages. We subsequently tried various methods to prepare liposomal curcumin, and eventually succeeded in preparing liposomes with sufficient amounts of curcumin to suppress macrophages by incorporating a complex of curcumin and bovine serum albumin. The diameter of the resultant nanoparticles, the liposomes containing curcumin, ranged from 60 to 100 nm. Flow cytometric analyses revealed that after intraperitoneal administration of the liposomes containing curcumin into mice, these were incorporated mainly by macrophages positive for F4/80, CD36, and CD11b antigens. Peritoneal cells prepared from mice injected in vivo with the liposomes containing curcumin apparently decreased interleukin-6-producing activities. Major changes in body weight and survival rates in the mice were not observed after administrating the liposomes containing curcumin. These results indicate that the liposomes containing curcumin are safe and useful for the selective suppression of macrophages in vivo in mice.

PMID:
26361331
PMCID:
PMC4567266
DOI:
10.1371/journal.pone.0137207
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Public Library of Science Icon for PubMed Central
Loading ...
Support Center