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Viruses. 2016 May 24;8(5). pii: E143. doi: 10.3390/v8050143.

Early Bunyavirus-Host Cell Interactions.

Author information

1
Molecular Virology Laboratory, Fundación Ciencia & Vida, Av. Zañartu 1482, 7780272 Santiago, Chile. aalbornoz@cienciavida.org.
2
CellNetworks-Cluster of Excellence and Department of Infectious Diseases, Virology, University Hospital Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany. anja.hoffmann@uni-heidelberg.de.
3
CellNetworks-Cluster of Excellence and Department of Infectious Diseases, Virology, University Hospital Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany. pierre-yves.lozach@med.uni-heidelberg.de.
4
Molecular Virology Laboratory, Fundación Ciencia & Vida, Av. Zañartu 1482, 7780272 Santiago, Chile. ntischler@cienciavida.org.

Abstract

The Bunyaviridae is the largest family of RNA viruses, with over 350 members worldwide. Several of these viruses cause severe diseases in livestock and humans. With an increasing number and frequency of outbreaks, bunyaviruses represent a growing threat to public health and agricultural productivity globally. Yet, the receptors, cellular factors and endocytic pathways used by these emerging pathogens to infect cells remain largely uncharacterized. The focus of this review is on the early steps of bunyavirus infection, from virus binding to penetration from endosomes. We address current knowledge and advances for members from each genus in the Bunyaviridae family regarding virus receptors, uptake, intracellular trafficking and fusion.

KEYWORDS:

RNA virus; bunyavirus; cell entry; endocytosis; hantavirus; tospovirus; virus membrane fusion; virus receptor

PMID:
27213430
PMCID:
PMC4885098
DOI:
10.3390/v8050143
[Indexed for MEDLINE]
Free PMC Article

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