Send to

Choose Destination
Food Chem Toxicol. 2008 Dec;46(12):3616-20. doi: 10.1016/j.fct.2008.09.008. Epub 2008 Sep 11.

Analysis of urinary andrographolides and antioxidant status after oral administration of Andrographis paniculata leaf extract in rats.

Author information

University College Sedaya International, Taman Connaught, 56000 Cheras, Kuala Lumpur, Malaysia.


A simple high-performance liquid chromatography (HPLC) method was developed to determine the content of andrographolide (AP) and 14-deoxy-11,12-dideoxyandrographolide (DIAP) in a pooled urine of rat obtained within 24h after an oral dose of Andrographis paniculata leaf extract at 1g/kg body weight. Cumulative urinary excretion of AP and DIAP in 24h after oral administration of the extract was 0.88% and 1.61% of oral dose administered, respectively. The extract showed significant reduction (p<0.05) of MDA levels and elevation of total antioxidant status in rat urine samples collected in 24 after oral administration.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center