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Hepatoprotective Effect of Steroidal Glycosides From Dioscorea villosa on Hydrogen Peroxide-Induced Hepatotoxicity in HepG2 Cells.

Siddiqui MA, Ali Z, Chittiboyina AG, Khan IA.

Front Pharmacol. 2018 Jul 23;9:797. doi: 10.3389/fphar.2018.00797. eCollection 2018.


A single molecular marker to distinguish between species of Dioscorea.

Techen N, Parveen I, Khan IA.

Genome. 2017 Mar;60(3):201-207. doi: 10.1139/gen-2015-0105. Epub 2016 Nov 3.


Gene expression profiling and pathway analysis data in MCF-7 and MDA-MB-231 human breast cancer cell lines treated with dioscin.

Aumsuwan P, Khan SI, Khan IA, Walker LA, Dasmahapatra AK.

Data Brief. 2016 May 25;8:272-9. doi: 10.1016/j.dib.2016.05.040. eCollection 2016 Sep.


The anticancer potential of steroidal saponin, dioscin, isolated from wild yam (Dioscorea villosa) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro.

Aumsuwan P, Khan SI, Khan IA, Ali Z, Avula B, Walker LA, Shariat-Madar Z, Helferich WG, Katzenellenbogen BS, Dasmahapatra AK.

Arch Biochem Biophys. 2016 Feb 1;591:98-110. doi: 10.1016/ Epub 2015 Dec 10.


A molecular docking study of phytochemical estrogen mimics from dietary herbal supplements.

Powers CN, Setzer WN.

In Silico Pharmacol. 2015 Mar 22;3:4. doi: 10.1186/s40203-015-0008-z. eCollection 2015.


Evaluation of wild yam (Dioscorea villosa) root extract as a potential epigenetic agent in breast cancer cells.

Aumsuwan P, Khan SI, Khan IA, Avula B, Walker LA, Helferich WG, Katzenellenbogen BS, Dasmahapatra AK.

In Vitro Cell Dev Biol Anim. 2015 Jan;51(1):59-71. doi: 10.1007/s11626-014-9807-5. Epub 2014 Aug 23.


Effect of liquid crystals with cyclodextrin on the bioavailability of a poorly water-soluble compound, diosgenin, after its oral administration to rats.

Okawara M, Hashimoto F, Todo H, Sugibayashi K, Tokudome Y.

Int J Pharm. 2014 Sep 10;472(1-2):257-61. doi: 10.1016/j.ijpharm.2014.06.032. Epub 2014 Jun 19.


Characterization of steroidal saponins from Dioscorea villosa and D. cayenensis using ultrahigh performance liquid chromatography/electrospray ionization quadrupole time-of-flight mass spectrometry.

Avula B, Wang YH, Wang M, Ali Z, Smillie TJ, Zweigenbaum J, Khan IA.

Planta Med. 2014 Mar;80(4):321-9. doi: 10.1055/s-0033-1360330. Epub 2014 Feb 7.


Effect of β-cyclodextrin derivatives on the diosgenin absorption in Caco-2 cell monolayer and rats.

Okawara M, Tokudome Y, Todo H, Sugibayashi K, Hashimoto F.

Biol Pharm Bull. 2014;37(1):54-9.


Herbal preparations for the menopause: beyond isoflavones and black cohosh.

Depypere HT, Comhaire FH.

Maturitas. 2014 Feb;77(2):191-4. doi: 10.1016/j.maturitas.2013.11.001. Epub 2013 Nov 19. Review.


High throughput screening of natural products for anti-mitotic effects in MDA-MB-231 human breast carcinoma cells.

Mazzio E, Badisa R, Mack N, Deiab S, Soliman KF.

Phytother Res. 2014 Jun;28(6):856-67. doi: 10.1002/ptr.5065. Epub 2013 Sep 17.


Chemical fingerprint analysis and quantitative determination of steroidal compounds from Dioscorea villosa, Dioscorea species and dietary supplements using UHPLC-ELSD.

Avula B, Wang YH, Ali Z, Smillie TJ, Khan IA.

Biomed Chromatogr. 2014 Feb;28(2):281-94. doi: 10.1002/bmc.3019. Epub 2013 Sep 10.


Characterization of in vitro ADME properties of diosgenin and dioscin from Dioscorea villosa.

Manda VK, Avula B, Ali Z, Wong YH, Smillie TJ, Khan IA, Khan SI.

Planta Med. 2013 Oct;79(15):1421-8. doi: 10.1055/s-0033-1350699. Epub 2013 Aug 22.


Lipidated steroid saponins from Dioscorea villosa (wild yam).

Dong SH, Cai G, Napolitano JG, Nikolić D, Lankin DC, McAlpine JB, van Breemen RB, Soejarto DD, Pauli GF, Chen SN.

Fitoterapia. 2013 Dec;91:113-124. doi: 10.1016/j.fitote.2013.07.018. Epub 2013 Aug 19.


Bioassay-guided evaluation of Dioscorea villosa - an acute and subchronic toxicity, antinociceptive and anti-inflammatory approach.

Lima CM, Lima AK, Melo MG, Serafini MR, Oliveira DL, de Almeida EB, Barreto RS, Nogueira PC, Moraes VR, Oliveira ER, de Albuquerque RL Jr, Quintans-Júnior LJ, Araújo AA.

BMC Complement Altern Med. 2013 Jul 28;13:195. doi: 10.1186/1472-6882-13-195.


Cholestane steroid glycosides from the rhizomes of Dioscorea villosa (wild yam).

Ali Z, Smillie TJ, Khan IA.

Carbohydr Res. 2013 Apr 5;370:86-91. doi: 10.1016/j.carres.2012.12.022. Epub 2013 Jan 9.


Enhancement of diosgenin distribution in the skin by cyclodextrin complexation following oral administration.

Okawara M, Tokudome Y, Todo H, Sugibayashi K, Hashimoto F.

Biol Pharm Bull. 2013;36(1):36-40.


Diarylheptanoids from Dioscorea villosa (Wild Yam).

Dong SH, Nikolić D, Simmler C, Qiu F, van Breemen RB, Soejarto DD, Pauli GF, Chen SN.

J Nat Prod. 2012 Dec 28;75(12):2168-77. doi: 10.1021/np300603z. Epub 2012 Dec 17. Erratum in: J Nat Prod. 2013 Oct 25;76(10):2005-7.


Application of high-speed countercurrent chromatography-evaporative light scattering detection for the separation of seven steroidal saponins from Dioscorea villosa.

Yoon KD, Chin YW, Yang MH, Choi J, Kim J.

Phytochem Anal. 2012 Sep-Oct;23(5):462-8. doi: 10.1002/pca.2342. Epub 2012 Mar 9.


Novel effects of diosgenin on skin aging.

Tada Y, Kanda N, Haratake A, Tobiishi M, Uchiwa H, Watanabe S.

Steroids. 2009 Jun;74(6):504-11. doi: 10.1016/j.steroids.2009.01.006. Epub 2009 Jan 31.


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