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Items: 1 to 20 of 522

1.

Targeting Histone Deacetylases in Myeloid Cells Inhibits Their Maturation and Inflammatory Function With Limited Effects on Atherosclerosis.

Luque-Martin R, Van den Bossche J, Furze RC, Neele AE, van der Velden S, Gijbels MJJ, van Roomen CPPA, Bernard SG, de Jonge WJ, Rioja I, Prinjha RK, Lewis HD, Mander PK, de Winther MPJ.

Front Pharmacol. 2019 Oct 29;10:1242. doi: 10.3389/fphar.2019.01242. eCollection 2019.

2.

Non-activatable mutant of inhibitor of kappa B kinase α (IKKα) exerts vascular site-specific effects on atherosclerosis in Apoe-deficient mice.

Tilstam PV, Soppert J, Hemmers C, Harlacher E, Döring Y, van der Vorst EPC, Schulte C, Alampour-Rajabi S, Theelen W, Asare Y, de Winther MPJ, Lawrence T, Bernhagen J, Schober A, Zernecke A, Jankowski J, Weber C, Noels H.

Atherosclerosis. 2019 Nov 2;292:23-30. doi: 10.1016/j.atherosclerosis.2019.10.023. [Epub ahead of print]

PMID:
31733453
3.

A genome-wide DNA methylation signature for SETD1B-related syndrome.

Krzyzewska IM, Maas SM, Henneman P, Lip KVD, Venema A, Baranano K, Chassevent A, Aref-Eshghi E, van Essen AJ, Fukuda T, Ikeda H, Jacquemont M, Kim HG, Labalme A, Lewis SME, Lesca G, Madrigal I, Mahida S, Matsumoto N, Rabionet R, Rajcan-Separovic E, Qiao Y, Sadikovic B, Saitsu H, Sweetser DA, Alders M, Mannens MMAM.

Clin Epigenetics. 2019 Nov 4;11(1):156. doi: 10.1186/s13148-019-0749-3.

4.

Prevalence and determinants of type 2 diabetes among lean African migrants and non-migrants: the RODAM study.

Chilunga FP, Henneman P, Meeks KA, Beune E, Requena-Méndez A, Smeeth L, Addo J, Bahendeka S, Danquah I, Schulze MB, Spranger J, Owusu-Dabo E, Klipstein-Grobusch K, Mannens MM, Agyemang C.

J Glob Health. 2019 Dec;9(2):020426. doi: 10.7189/jogh.09.020426.

5.

Salt increases monocyte CCR2 expression and inflammatory responses in humans.

Wenstedt EF, Verberk SG, Kroon J, Neele AE, Baardman J, Claessen N, Pasaoglu ÖT, Rademaker E, Schrooten EM, Wouda RD, de Winther MP, Aten J, Vogt L, Van den Bossche J.

JCI Insight. 2019 Nov 1;4(21). pii: 130508. doi: 10.1172/jci.insight.130508.

6.

Painful interactions: Microbial compounds and visceral pain.

van Thiel IAM, Botschuijver S, de Jonge WJ, Seppen J.

Biochim Biophys Acta Mol Basis Dis. 2020 Jan 1;1866(1):165534. doi: 10.1016/j.bbadis.2019.165534. Epub 2019 Oct 18. Review.

7.

Transcriptional and epigenetic regulation of macrophages in atherosclerosis.

Kuznetsova T, Prange KHM, Glass CK, de Winther MPJ.

Nat Rev Cardiol. 2019 Oct 2. doi: 10.1038/s41569-019-0265-3. [Epub ahead of print] Review.

PMID:
31578516
8.

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer.

Burr ML, Sparbier CE, Chan KL, Chan YC, Kersbergen A, Lam EYN, Azidis-Yates E, Vassiliadis D, Bell CC, Gilan O, Jackson S, Tan L, Wong SQ, Hollizeck S, Michalak EM, Siddle HV, McCabe MT, Prinjha RK, Guerra GR, Solomon BJ, Sandhu S, Dawson SJ, Beavis PA, Tothill RW, Cullinane C, Lehner PJ, Sutherland KD, Dawson MA.

Cancer Cell. 2019 Oct 14;36(4):385-401.e8. doi: 10.1016/j.ccell.2019.08.008. Epub 2019 Sep 26.

9.

Miltefosine treatment reduces visceral hypersensitivity in a rat model for irritable bowel syndrome via multiple mechanisms.

Botschuijver S, van Diest SA, van Thiel IAM, Saia RS, Strik AS, Yu Z, Maria-Ferreira D, Welting O, Keszthelyi D, Jennings G, Heinsbroek SEM, Elferink RPO, Schuren FHJ, de Jonge WJ, van den Wijngaard RM.

Sci Rep. 2019 Aug 29;9(1):12530. doi: 10.1038/s41598-019-49096-y.

10.

A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification.

Bamborough P, Chung CW, Demont EH, Bridges AM, Craggs PD, Dixon DP, Francis P, Furze RC, Grandi P, Jones EJ, Karamshi B, Locke K, Lucas SCC, Michon AM, Mitchell DJ, Pogány P, Prinjha RK, Rau C, Roa AM, Roberts AD, Sheppard RJ, Watson RJ.

J Med Chem. 2019 Aug 22;62(16):7506-7525. doi: 10.1021/acs.jmedchem.9b00673. Epub 2019 Aug 9.

PMID:
31398032
11.

Acetylcholine-producing T cells augment innate immune-driven colitis but are redundant in T cell-driven colitis.

Willemze RA, Brinkman DJ, Welting O, van Hamersveld PHP, Verseijden C, Luyer MD, Wildenberg ME, Seppen J, de Jonge WJ.

Am J Physiol Gastrointest Liver Physiol. 2019 Nov 1;317(5):G557-G568. doi: 10.1152/ajpgi.00067.2019. Epub 2019 Jul 19.

PMID:
31322912
12.

Neuroimmune Interactions in the Gut and Their Significance for Intestinal Immunity.

Brinkman DJ, Ten Hove AS, Vervoordeldonk MJ, Luyer MD, de Jonge WJ.

Cells. 2019 Jul 2;8(7). pii: E670. doi: 10.3390/cells8070670. Review.

13.

Nanoparticle-Aided Characterization of Arterial Endothelial Architecture during Atherosclerosis Progression and Metabolic Therapy.

Beldman TJ, Malinova TS, Desclos E, Grootemaat AE, Misiak ALS, van der Velden S, van Roomen CPAA, Beckers L, van Veen HA, Krawczyk PM, Hoebe RA, Sluimer JC, Neele AE, de Winther MPJ, van der Wel NN, Lutgens E, Mulder WJM, Huveneers S, Kluza E.

ACS Nano. 2019 Jul 10. doi: 10.1021/acsnano.8b08875. [Epub ahead of print]

PMID:
31268670
14.

BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity.

Khoueiry P, Ward Gahlawat A, Petretich M, Michon AM, Simola D, Lam E, Furlong EE, Benes V, Dawson MA, Prinjha RK, Drewes G, Grandi P.

Epigenetics Chromatin. 2019 Jul 2;12(1):39. doi: 10.1186/s13072-019-0286-5.

15.

Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss.

Fedoriw A, Rajapurkar SR, O'Brien S, Gerhart SV, Mitchell LH, Adams ND, Rioux N, Lingaraj T, Ribich SA, Pappalardi MB, Shah N, Laraio J, Liu Y, Butticello M, Carpenter CL, Creasy C, Korenchuk S, McCabe MT, McHugh CF, Nagarajan R, Wagner C, Zappacosta F, Annan R, Concha NO, Thomas RA, Hart TK, Smith JJ, Copeland RA, Moyer MP, Campbell J, Stickland K, Mills J, Jacques-O'Hagan S, Allain C, Johnston D, Raimondi A, Porter Scott M, Waters N, Swinger K, Boriack-Sjodin A, Riera T, Shapiro G, Chesworth R, Prinjha RK, Kruger RG, Barbash O, Mohammad HP.

Cancer Cell. 2019 Jul 8;36(1):100-114.e25. doi: 10.1016/j.ccell.2019.05.014. Epub 2019 Jun 27.

PMID:
31257072
16.

Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia.

Bell CC, Fennell KA, Chan YC, Rambow F, Yeung MM, Vassiliadis D, Lara L, Yeh P, Martelotto LG, Rogiers A, Kremer BE, Barbash O, Mohammad HP, Johanson TM, Burr ML, Dhar A, Karpinich N, Tian L, Tyler DS, MacPherson L, Shi J, Pinnawala N, Yew Fong C, Papenfuss AT, Grimmond SM, Dawson SJ, Allan RS, Kruger RG, Vakoc CR, Goode DL, Naik SH, Gilan O, Lam EYN, Marine JC, Prinjha RK, Dawson MA.

Nat Commun. 2019 Jun 20;10(1):2723. doi: 10.1038/s41467-019-10652-9.

17.

Bromodomain inhibitor I-BET151 suppresses immune responses during fungal-immune interaction.

Domínguez-Andrés J, Ferreira AV, Jansen T, Smithers N, Prinjha RK, Furze RC, Netea MG.

Eur J Immunol. 2019 Nov;49(11):2044-2050. doi: 10.1002/eji.201848081. Epub 2019 Jun 21.

PMID:
31206650
18.

Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia.

Bekkering S, Stiekema LCA, Bernelot Moens S, Verweij SL, Novakovic B, Prange K, Versloot M, Roeters van Lennep JE, Stunnenberg H, de Winther M, Stroes ESG, Joosten LAB, Netea MG, Riksen NP.

Cell Metab. 2019 Jul 2;30(1):1-2. doi: 10.1016/j.cmet.2019.05.014. Epub 2019 Jun 13.

PMID:
31204280
19.

Human monocyte-to-macrophage differentiation involves highly localized gain and loss of DNA methylation at transcription factor binding sites.

Dekkers KF, Neele AE, Jukema JW, Heijmans BT, de Winther MPJ.

Epigenetics Chromatin. 2019 Jun 6;12(1):34. doi: 10.1186/s13072-019-0279-4.

20.

Leducq Epigenetics of Atherosclerosis Network.

de Winther MPJ, Glass CK.

Circ Res. 2019 Jun 7;124(12):1697-1700. doi: 10.1161/CIRCRESAHA.119.315187. Epub 2019 Jun 6. No abstract available.

PMID:
31170047

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