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Genes Dev. 2007 Dec 15;21(24):3238-43.

A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells.

Author information

1
Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

Abstract

microRNA (miRNA) expression profiles are often characteristic of specific cell types. The mouse mammary epithelial cell line, Comma-Dbeta, contains a population of self-renewing progenitor cells that can reconstitute the mammary gland. We purified this population and determined its miRNA signature. Several microRNAs, including miR-205 and miR-22, are highly expressed in mammary progenitor cells, while others, including let-7 and miR-93, are depleted. Let-7 sensors can be used to prospectively enrich self-renewing populations, and enforced let-7 expression induces loss of self-renewing cells from mixed cultures.

PMID:
18079172
PMCID:
PMC2113025
DOI:
10.1101/gad.1616307
[Indexed for MEDLINE]
Free PMC Article

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