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Nat Rev Cancer. 2007 Nov;7(11):819-22. doi: 10.1038/nrc2232.

microRNAs join the p53 network--another piece in the tumour-suppression puzzle.

Author information

1
Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.

Abstract

Several recent studies have found a conserved microRNA (miRNA) family, the miR-34s, to be direct transcriptional targets of p53. miR-34 activation can recapitulate elements of p53 activity, including induction of cell-cycle arrest and promotion of apoptosis, and loss of miR-34 can impair p53-mediated cell death. These data reinforce the growing awareness that non-coding RNAs are key players in tumour development by placing miRNAs in a central role in a well-known tumour-suppressor network.

PMID:
17914404
PMCID:
PMC4053212
DOI:
10.1038/nrc2232
[Indexed for MEDLINE]
Free PMC Article

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